Safety and Health at Work Vol. 11 Issue 2 2020
Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company (Original Article)
Dublin Core
Title
Safety and Health at Work Vol. 11 Issue 2 2020
Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company (Original Article)
Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company (Original Article)
Subject
Cadmium, Occupational exposure, Renal dysfunction, Soldering
Description
Background: Cadmium exposure may induce chronic intoxication with renal damage. Silver soldering may be a source of cadmium exposure.
Methods: We analyzed working environment measurement data and periodic health screening data from a small-scale silver soldering company with ten workers. Concentrations of cadmium in air from working environment measurement data were obtained. Concentrations of blood and urinary cadmium, urine protein, and urine b2-microglobulin (b2M) were obtained. The generalized linear model was used to identify the association between blood and urine cadmium and urine b2M concentrations. Clinical features of chronic cadmium intoxication focused with toxicological renal effects were described.
Results: The mean duration of work was 8.5 years (standard deviation [SD] 1⁄4 6.9, range 1⁄4 3e20 years). Cadmium concentrations in air were ranged from 0.006 to 0.015 mg/m3 . Blood cadmium concentration was elevated in all ten workers, with a highest level of 34.6 mg/L (mean 1⁄4 21.288 mg/L, SD 1⁄4 11.304, range 1⁄4 9.641e34.630 mg/L). Urinary cadmium concentration was elevated in nine workers, with a highest level of 62.9 mg/g Cr (mean 1⁄4 22.151 mg/g creatinine, SD 1⁄4 19.889, range 1⁄4 3.228e62.971 mg/g creatinine). Urine b2M concentration was elevated in three workers. Urinary cadmium concentration was positively
associated with urine protein concentration (beta coefficient 1⁄4 10.27, 95% confidence interval 1⁄4 [4.36, 16.18]). Other clinical parameters were compatible with renal tubular damage.
Conclusion: Cadmium intoxication may occur at quite low air concentrations. Exposure limit may be
needed to be lowered.
Methods: We analyzed working environment measurement data and periodic health screening data from a small-scale silver soldering company with ten workers. Concentrations of cadmium in air from working environment measurement data were obtained. Concentrations of blood and urinary cadmium, urine protein, and urine b2-microglobulin (b2M) were obtained. The generalized linear model was used to identify the association between blood and urine cadmium and urine b2M concentrations. Clinical features of chronic cadmium intoxication focused with toxicological renal effects were described.
Results: The mean duration of work was 8.5 years (standard deviation [SD] 1⁄4 6.9, range 1⁄4 3e20 years). Cadmium concentrations in air were ranged from 0.006 to 0.015 mg/m3 . Blood cadmium concentration was elevated in all ten workers, with a highest level of 34.6 mg/L (mean 1⁄4 21.288 mg/L, SD 1⁄4 11.304, range 1⁄4 9.641e34.630 mg/L). Urinary cadmium concentration was elevated in nine workers, with a highest level of 62.9 mg/g Cr (mean 1⁄4 22.151 mg/g creatinine, SD 1⁄4 19.889, range 1⁄4 3.228e62.971 mg/g creatinine). Urine b2M concentration was elevated in three workers. Urinary cadmium concentration was positively
associated with urine protein concentration (beta coefficient 1⁄4 10.27, 95% confidence interval 1⁄4 [4.36, 16.18]). Other clinical parameters were compatible with renal tubular damage.
Conclusion: Cadmium intoxication may occur at quite low air concentrations. Exposure limit may be
needed to be lowered.
Creator
Won-Jun Choi, Seong-Kyu Kang, Seunghon Ham, Wookyung Chung, Ae Jin Kim, Myunghee Kang
Publisher
Elsevier Korea LLC
Date
June 2020
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 11 Issue 2 2020
Files
Citation
Won-Jun Choi, Seong-Kyu Kang, Seunghon Ham, Wookyung Chung, Ae Jin Kim, Myunghee Kang, “Safety and Health at Work Vol. 11 Issue 2 2020
Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company (Original Article),” Repository Horizon University Indonesia, accessed December 3, 2024, https://repository.horizon.ac.id/items/show/1984.
Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company (Original Article),” Repository Horizon University Indonesia, accessed December 3, 2024, https://repository.horizon.ac.id/items/show/1984.