Jurnal Internasional Afrika vol.12 issue 4 2022
African Journal of Emergency Medicine
Prevalence and presentation of neonatal sepsis at a paediatric emergency department in Johannesburg, South Africa

Jurnal Internasional Afrika vol.12 issue 4 2022
African Journal of Emergency Medicine
Prevalence and presentation of neonatal sepsis at a paediatric emergency department in Johannesburg, South Africa

Neonatal sepsis Emergency centre Perinatal HIV exposure Preterm birth Low birth weight Breast feeding

Background: Despite a significant reduction in the prevalence of neonatal sepsis over the past three decades, the prevalence still remains high, especially in low- and middle-income countries. The aim of this study was to determine the prevalence and presenting features of neonatal sepsis at a paediatric emergency centre (PEC). Methods: Medical records of all neonates presenting to an academic hospital PEC over a six-month period were analysed. Data was compared between neonates with and without sepsis. The odds ratio was calculated to deter- mine factors associated with neonatal sepsis. Results: Of the 210 neonates who were included, 43 (20.5%) were diagnosed with neonatal sepsis. Of these, 19 (44.2%) presented within the first 72 hours of life (early-onset neonatal sepsis) and 4 (9.3%) died prior to hospital discharge. A history of maternal employment (odds ratio (OR) 2.38, p = 0.021), preterm birth (OR 3.24, p = 0.019), low birth weight ( < 2.5kg) (OR 2.67, p = 0.026), perinatal human immunodeficiency virus exposure (OR 3.35, p = 0.002), not being breast fed (OR 4.36, p = 0.001), and signs of lethargy (OR 14.01, p < 0.001), dehydration (or 11.14, p < 0.001), poor feeding (OR 7.20, p < 0.001), irritability (OR 6.93, p < 0.001), fever (OR 5.50, p < 0.001), vomiting (OR 4.14, p < 0.001) and respiratory distress (OR 4.12, p < 0.001) were significantly associated with neonatal sepsis. Conclusion: Among neonates presenting to the PEC, various clinical features on history and examination may be useful in predicting the diagnosis of neonatal sepsis. Clinicians working in the PEC must adopt a high index of suspicion when attending to neonates presenting with these features

Tchouambou SN Clotilde, Feroza Motara, AbdullahE Laher

www.elsevier.com/locate/afjem

elsavier

24 July 2022

peri irawan

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