Safety and Health at Work Vol. 13 Issue 1 2022
Letter to the Editor Regarding “Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies” (Letter to the Editor)
Dublin Core
Title
Safety and Health at Work Vol. 13 Issue 1 2022
Letter to the Editor Regarding “Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies” (Letter to the Editor)
Letter to the Editor Regarding “Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies” (Letter to the Editor)
Subject
Risk Assesment, Toluene Diisocyanate, Respiratory Disease
Description
To the Editor,
We would like to provide comments on an article by Park [1] that was recently published in Safety and Health at Work. The article describes an alternative method to address healthy worker effect (HWE) bias as it relates to the interpretation of asthma studies. It would appear that the author’s intent was to re-assess existing epidemiology studies on toluene diisocyanate (TDI) exposure and asthma and to correct the published data for the potential existence of a healthy-worker-effect (HWE) prior to performing a risk assessment. A risk assessment approach should be based upon: (A) use of a validated model, (B) transparent selection criteria for studies included, (C) verification of model adequacy, and (D) assumptions supported by literature. As outlined below, we believe that the publication [1] has significant shortcomings with regard to these basic principles.
We would like to provide comments on an article by Park [1] that was recently published in Safety and Health at Work. The article describes an alternative method to address healthy worker effect (HWE) bias as it relates to the interpretation of asthma studies. It would appear that the author’s intent was to re-assess existing epidemiology studies on toluene diisocyanate (TDI) exposure and asthma and to correct the published data for the potential existence of a healthy-worker-effect (HWE) prior to performing a risk assessment. A risk assessment approach should be based upon: (A) use of a validated model, (B) transparent selection criteria for studies included, (C) verification of model adequacy, and (D) assumptions supported by literature. As outlined below, we believe that the publication [1] has significant shortcomings with regard to these basic principles.
Creator
Sahar Osman-Sypher
Publisher
Elsevier Korea LLC
Date
March 2022
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 13 Issue 1 2022
Files
Citation
Sahar Osman-Sypher, “Safety and Health at Work Vol. 13 Issue 1 2022
Letter to the Editor Regarding “Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies” (Letter to the Editor),” Repository Horizon University Indonesia, accessed April 4, 2025, https://repository.horizon.ac.id/items/show/2251.
Letter to the Editor Regarding “Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies” (Letter to the Editor),” Repository Horizon University Indonesia, accessed April 4, 2025, https://repository.horizon.ac.id/items/show/2251.