Safety and Health at Work Vol. 13 Supplement 1 2022
Working environment and urinary 8-hydroxy-2’-deoxyguanosine as an oxidative stress marker
Dublin Core
Title
Safety and Health at Work Vol. 13 Supplement 1 2022
Working environment and urinary 8-hydroxy-2’-deoxyguanosine as an oxidative stress marker
Working environment and urinary 8-hydroxy-2’-deoxyguanosine as an oxidative stress marker
Subject
Working environment, urinary 8-hydroxy-2’-deoxyguanosine, oxidative stress marker
Description
Introduction: Oxidative stress is associated with numerous occupational exposures. Urinary 8-hydroxy-2’-deoxyguanosine (8- OHdG) is widely analyzed as a typical oxidative stress marker. We seek to clarify the relationship between urinary 8-OHdG levels and the working environment.
Materials methods: We investigated the relationships between working environments: smoking, organic solvent or hydrochloric acid exposure, shiftwork, and sunlight exposure, and the urinary 8-OHdG levels in 503 male workers. The study was approved by the Ethics Committee of Medical Research, University of Occupational and Environmental Health, Japan.
Results: Workers handling organic solvents or hydrochloric acid had high urinary 8-OHdG levels. In non-smokers, workers handling organic solvents or hydrochloric acid and shift workers had high 8-OHdG levels. There were no significant variations in urinary 8-OHdG levels due to other differences in the working environment.
Conclusion: We suggest that exposure to organic solvents or hydrochloric acid may increase oxidative stress in workers. In this study, the working environment was evaluated based on a self-administered questionnaire survey. Further investigations with quantitative evaluations of the working environment may be needed.
Acknowledgement: This work was supported by JSPS KAKENHI
Grant Number JP17H01908.
Materials methods: We investigated the relationships between working environments: smoking, organic solvent or hydrochloric acid exposure, shiftwork, and sunlight exposure, and the urinary 8-OHdG levels in 503 male workers. The study was approved by the Ethics Committee of Medical Research, University of Occupational and Environmental Health, Japan.
Results: Workers handling organic solvents or hydrochloric acid had high urinary 8-OHdG levels. In non-smokers, workers handling organic solvents or hydrochloric acid and shift workers had high 8-OHdG levels. There were no significant variations in urinary 8-OHdG levels due to other differences in the working environment.
Conclusion: We suggest that exposure to organic solvents or hydrochloric acid may increase oxidative stress in workers. In this study, the working environment was evaluated based on a self-administered questionnaire survey. Further investigations with quantitative evaluations of the working environment may be needed.
Acknowledgement: This work was supported by JSPS KAKENHI
Grant Number JP17H01908.
Creator
Sintaroo Watanabe, Yun-Shan Li, Yuko Ootsuyama, Kazuaki Kawai
Publisher
Elsevier Korea LLC
Date
January 2022
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 13 Supplement 1 2022
Files
Citation
Sintaroo Watanabe, Yun-Shan Li, Yuko Ootsuyama, Kazuaki Kawai, “Safety and Health at Work Vol. 13 Supplement 1 2022
Working environment and urinary 8-hydroxy-2’-deoxyguanosine as an oxidative stress marker,” Repository Horizon University Indonesia, accessed April 10, 2025, https://repository.horizon.ac.id/items/show/2352.
Working environment and urinary 8-hydroxy-2’-deoxyguanosine as an oxidative stress marker,” Repository Horizon University Indonesia, accessed April 10, 2025, https://repository.horizon.ac.id/items/show/2352.