Jurnal Internasional Afrika vol. 10 issue 1 2020
African Journal of Emergency Medicine
Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study
Dublin Core
Title
Jurnal Internasional Afrika vol. 10 issue 1 2020
African Journal of Emergency Medicine
Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study
African Journal of Emergency Medicine
Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study
Subject
Ebola virus disease
Mortality
Multivitamins
Nutrition
Liberia
Sierra Leone
Mortality
Multivitamins
Nutrition
Liberia
Sierra Leone
Description
Introduction: Micronutrient supplementation is recommended in Ebola Virus Disease (EVD) care; however, there
is limited data on its therapeutic effects.
Methods: This retrospective cohort study included patients with EVD admitted to five Ebola Treatment Units
(ETU) in Sierra Leone and Liberia during September 2014 to December 2015. A uniform protocol was used to
guide ETU care, however, due to supply limitations, only a subset of patients received multivitamins. Data on
demographics, clinical characteristics, and laboratory testing was collected. The outcome of interest was facilitybased
mortality and the primary predictor was multivitamin supplementation initiated within 48 h of admission.
The multivitamin formulations included: thiamine, riboflavin, niacin and vitamins A, C, and D3. Propensity score
models (PSM) were used to match patients based on covariates associated with multivitamin administration and
mortality. Mortality between cases treated and untreated within 48 h of admission were compared using generalized
estimating equations to calculate relative risk with bootstrap methods employed to assess statistical
significance.
Results: There were 424 patients with EVD who had sufficient treatment data for analysis, of which 261 (61.6%)
had daily multivitamins initiated within 48 h of admission. The mean age of the cohort was 30.5 years and
59.4% were female. In the propensity score matched analysis, mortality was 53.5% among patients receiving
multivitamins and 66.2% among patients not receiving multivitamins, resulting in a relative risk for mortality of
0.81 (p=0.03) for patients receiving multivitamins.
Conclusion: Early multivitamin supplementation was associated with lower overall mortality. Further research
on the impact of micronutrient supplementation in EVD is warranted.
is limited data on its therapeutic effects.
Methods: This retrospective cohort study included patients with EVD admitted to five Ebola Treatment Units
(ETU) in Sierra Leone and Liberia during September 2014 to December 2015. A uniform protocol was used to
guide ETU care, however, due to supply limitations, only a subset of patients received multivitamins. Data on
demographics, clinical characteristics, and laboratory testing was collected. The outcome of interest was facilitybased
mortality and the primary predictor was multivitamin supplementation initiated within 48 h of admission.
The multivitamin formulations included: thiamine, riboflavin, niacin and vitamins A, C, and D3. Propensity score
models (PSM) were used to match patients based on covariates associated with multivitamin administration and
mortality. Mortality between cases treated and untreated within 48 h of admission were compared using generalized
estimating equations to calculate relative risk with bootstrap methods employed to assess statistical
significance.
Results: There were 424 patients with EVD who had sufficient treatment data for analysis, of which 261 (61.6%)
had daily multivitamins initiated within 48 h of admission. The mean age of the cohort was 30.5 years and
59.4% were female. In the propensity score matched analysis, mortality was 53.5% among patients receiving
multivitamins and 66.2% among patients not receiving multivitamins, resulting in a relative risk for mortality of
0.81 (p=0.03) for patients receiving multivitamins.
Conclusion: Early multivitamin supplementation was associated with lower overall mortality. Further research
on the impact of micronutrient supplementation in EVD is warranted.
Creator
Derrick Yam, Adam R. Aluisio, Shiromi M. Perera, Jillian L. Peters, Daniel K. Cho, Stephen B. Kennedy, Moses Massaquoi, Foday Sahr, Michael A. Smit, Lindsey Locks, Tao Liu, Adam C. Levine
Source
www.elsevier.com/locate/afjem
Date
1 November 2019
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Derrick Yam, Adam R. Aluisio, Shiromi M. Perera, Jillian L. Peters, Daniel K. Cho, Stephen B. Kennedy, Moses Massaquoi, Foday Sahr, Michael A. Smit, Lindsey Locks, Tao Liu, Adam C. Levine, “Jurnal Internasional Afrika vol. 10 issue 1 2020
African Journal of Emergency Medicine
Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study,” Repository Horizon University Indonesia, accessed April 19, 2025, https://repository.horizon.ac.id/items/show/2411.
African Journal of Emergency Medicine
Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study,” Repository Horizon University Indonesia, accessed April 19, 2025, https://repository.horizon.ac.id/items/show/2411.