Safety and Health at Work Vol. 13 Supplement 2022
Do microRNAs characterize exposure and asbestos-related diseases?
Dublin Core
Title
Safety and Health at Work Vol. 13 Supplement 2022
Do microRNAs characterize exposure and asbestos-related diseases?
Do microRNAs characterize exposure and asbestos-related diseases?
Subject
microRNAs characterize, exposure, asbestos,diseases
Description
Introduction: Asbestos-related diseases can be latent for long time after exposure cessation. We analyzed the expression of a set of 179 microRNAs in the plasma these workers in search of relevant microRNAs as biomarkers, regulators of disease pathways and potential targets for risk assessment. Furthermore, the study was designed to evaluate longitudinal changes in microRNA patterns in each subject for a personalized management of the disease course.
Subjects and methods: Asymptomatic high-risk workers were enrolled. Plasma was obtained to extract and analyze the microRNAs through biomolecular techniques and specialized instrumentation. Data were compared to those obtained by control subjects (not exposed, N1⁄430). The present study was approved by the local Ethical Committee.
Results: Ex-asbestos workers (n1⁄47, analyzed individually and as a pool) showed a pattern of overexpressed microRNAs, a subset of which already described as mesothelioma-related miR. Other mesothelioma-linked microRNAs were not detected in these workers. Other were variably expressed amongst subjects.
Conclusion: Up-regulated microRNA might represent early footprint of the dysregulation associated with occupational exposure to asbestos. Not expressed and variably expressed miR might may represent a biomarker of pre-clinical disease after validation in larger cohort of subjects and if confirmed by comparison with subject-matched prospective clinical data. The evaluation of (patterns) of the miRs highlighted here might be interesting to monitor disease onset/progression and help to define asbestos-oriented health surveillance protocols.
Subjects and methods: Asymptomatic high-risk workers were enrolled. Plasma was obtained to extract and analyze the microRNAs through biomolecular techniques and specialized instrumentation. Data were compared to those obtained by control subjects (not exposed, N1⁄430). The present study was approved by the local Ethical Committee.
Results: Ex-asbestos workers (n1⁄47, analyzed individually and as a pool) showed a pattern of overexpressed microRNAs, a subset of which already described as mesothelioma-related miR. Other mesothelioma-linked microRNAs were not detected in these workers. Other were variably expressed amongst subjects.
Conclusion: Up-regulated microRNA might represent early footprint of the dysregulation associated with occupational exposure to asbestos. Not expressed and variably expressed miR might may represent a biomarker of pre-clinical disease after validation in larger cohort of subjects and if confirmed by comparison with subject-matched prospective clinical data. The evaluation of (patterns) of the miRs highlighted here might be interesting to monitor disease onset/progression and help to define asbestos-oriented health surveillance protocols.
Creator
Claudia Petrarca, Davide Viola, Rocco Mangifesta, Mario Di Gioacchino and Luca Di Giampaolo
Publisher
Elsevier Korea LLC
Date
January 2022
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 13 Supplement 2022
Files
Citation
Claudia Petrarca, Davide Viola, Rocco Mangifesta, Mario Di Gioacchino and Luca Di Giampaolo , “Safety and Health at Work Vol. 13 Supplement 2022
Do microRNAs characterize exposure and asbestos-related diseases?,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/2427.
Do microRNAs characterize exposure and asbestos-related diseases?,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/2427.