Jurnal Internasional Afrika vol. 11 issue 1 2021
African Journal of Emergency Medicine
Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: A prospective observational study
Dublin Core
Title
Jurnal Internasional Afrika vol. 11 issue 1 2021
African Journal of Emergency Medicine
Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: A prospective observational study
African Journal of Emergency Medicine
Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: A prospective observational study
Subject
Ethiopia
Mortality
Prevalence
Sepsis
Septic shock
Mortality
Prevalence
Sepsis
Septic shock
Description
Background: Sepsis and septic shock are the major causes of morbidity and mortality in Intensive care Units
(ICUs) in low and middle-income countries. However, little is known about their prevalence and outcome in
these settings. The study aimed to assess the prevalence and outcome of sepsis and septic shock in ICUs in Addis
Ababa, Ethiopia.
Methods: A prospective observational study was conducted from March 2017 to February 2018 in four selected
ICUs in Addis Ababa from a total of twelve hospitals having ICU services. There were 1145 total ICU admissions
during the study period. All admissions into those ICUs with sepsis, severe sepsis, and septic shock using the
Systemic Inflammatory Response Syndrome (SIRS) criteria (SEPSIS-2) during the study period were screened for
sepsis or septic shock based on the new sepsis definition (SEPSIS-3). All patients with sepsis and septic shock
during ICU admission were included and followed for 28 days of ICU admission. Data analysis was done using the
Statistical Package for Social Sciences (SPSS) software version 20.0.
Results: A total of 275 patients were diagnosed with sepsis and septic shock. The overall prevalence of sepsis and
septic shock was 26.5 per 100 ICU admissions. The most frequent source of sepsis was respiratory infection
(53.1%). The median length of stay in the ICUs was 5 (IQR, 2–8) days. The most common bacterium isolate was
Pseudomonas aeroginosa (34.5%). The ICU and 28-day mortality rate was 41.8% and 50.9% respectively. Male
sex, modified Sequential Organ Failure Assessment score ≥10 on day 1 of ICU admission, and comorbidity of HIV
or malignancy were the independent predictors of 28-day mortality.
Conclusion: Sepsis and septic shock are common among our ICU admissions, and are associated with a high
mortality rate.
(ICUs) in low and middle-income countries. However, little is known about their prevalence and outcome in
these settings. The study aimed to assess the prevalence and outcome of sepsis and septic shock in ICUs in Addis
Ababa, Ethiopia.
Methods: A prospective observational study was conducted from March 2017 to February 2018 in four selected
ICUs in Addis Ababa from a total of twelve hospitals having ICU services. There were 1145 total ICU admissions
during the study period. All admissions into those ICUs with sepsis, severe sepsis, and septic shock using the
Systemic Inflammatory Response Syndrome (SIRS) criteria (SEPSIS-2) during the study period were screened for
sepsis or septic shock based on the new sepsis definition (SEPSIS-3). All patients with sepsis and septic shock
during ICU admission were included and followed for 28 days of ICU admission. Data analysis was done using the
Statistical Package for Social Sciences (SPSS) software version 20.0.
Results: A total of 275 patients were diagnosed with sepsis and septic shock. The overall prevalence of sepsis and
septic shock was 26.5 per 100 ICU admissions. The most frequent source of sepsis was respiratory infection
(53.1%). The median length of stay in the ICUs was 5 (IQR, 2–8) days. The most common bacterium isolate was
Pseudomonas aeroginosa (34.5%). The ICU and 28-day mortality rate was 41.8% and 50.9% respectively. Male
sex, modified Sequential Organ Failure Assessment score ≥10 on day 1 of ICU admission, and comorbidity of HIV
or malignancy were the independent predictors of 28-day mortality.
Conclusion: Sepsis and septic shock are common among our ICU admissions, and are associated with a high
mortality rate.
Creator
Hailu Abera Mulatu , Tola Bayisa , Yoseph Worku , John J. Lazarus , Esubalew Woldeyes , Dawit Bacha , Bisrat Taye , Mamo Nigussie , Hamelmal Gebeyehu, Azeb Kebede
Source
www.elsevier.com/locate/afjem
Publisher
elsevier
Date
2 October 2020
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Hailu Abera Mulatu , Tola Bayisa , Yoseph Worku , John J. Lazarus , Esubalew Woldeyes , Dawit Bacha , Bisrat Taye , Mamo Nigussie , Hamelmal Gebeyehu, Azeb Kebede, “Jurnal Internasional Afrika vol. 11 issue 1 2021
African Journal of Emergency Medicine
Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: A prospective observational study,” Repository Horizon University Indonesia, accessed April 26, 2025, https://repository.horizon.ac.id/items/show/2497.
African Journal of Emergency Medicine
Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Ababa, Ethiopia: A prospective observational study,” Repository Horizon University Indonesia, accessed April 26, 2025, https://repository.horizon.ac.id/items/show/2497.