Safety and Health at Work Vol. 14 Issue 1 2023
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat (Original article)
Dublin Core
Title
Safety and Health at Work Vol. 14 Issue 1 2023
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat (Original article)
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat (Original article)
Subject
Silicosis, Vitamin D, Oxidative stress, Inflammation, TNF-a
Description
Background: Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease.
Method: In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days.
Results: Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-a (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica.
Conclusion: These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.
Method: In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days.
Results: Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-a (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica.
Conclusion: These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.
Creator
Maryam Esfahani, Amir Hossein Rahbar, Sara Soleimani Asl , Saed Bashirian,Effat Sadat Mir Moeini, Fereshteh Mehri
Publisher
Elsevier Korea LLC
Date
March 2023
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 14 Issue 1 2023
Files
Citation
Maryam Esfahani, Amir Hossein Rahbar, Sara Soleimani Asl , Saed Bashirian,Effat Sadat Mir Moeini, Fereshteh Mehri, “Safety and Health at Work Vol. 14 Issue 1 2023
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat (Original article),” Repository Horizon University Indonesia, accessed March 14, 2025, https://repository.horizon.ac.id/items/show/2595.
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat (Original article),” Repository Horizon University Indonesia, accessed March 14, 2025, https://repository.horizon.ac.id/items/show/2595.