PROSIDING INTERNASIONAL Proceedings of the International Conference on Nursing and Health Sciences, Volume 3 No 1, May 2022
IN SILICO ADME AND TOXICITY STUDIES OF DERIVATIVE PHTHALIMIDE COMPOUNDS AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITOR
Dublin Core
Title
PROSIDING INTERNASIONAL Proceedings of the International Conference on Nursing and Health Sciences, Volume 3 No 1, May 2022
IN SILICO ADME AND TOXICITY STUDIES OF DERIVATIVE PHTHALIMIDE COMPOUNDS AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITOR
IN SILICO ADME AND TOXICITY STUDIES OF DERIVATIVE PHTHALIMIDE COMPOUNDS AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITOR
Subject
HIV; phthalimide; SwissADME; toxtree
Description
Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase
inhibitors. The aim of this research is to determine the prediction of absorption, distribution, metabolism,
and excretion (ADME) as well as the toxicity test of phthalimide-derived compounds which have the best
potential as HIV-1 reverse transcriptase enzyme inhibitors. This study used an in silico approach to predict
oral bioavailability and toxicity. The prediction of the ADME in this study using SwissADME which is run
online where thirty-three phthalimide derivate compounds have molecular weight, hydrogen donor and
acceptor bond, and log P that meet the criteria of Lipinski Rules. Prediction of toxicity in this study using
in silico method with Toxtree v1.60 and it is known that phthalimide derivate compounds are not
carcinogenic and mutagenic.
inhibitors. The aim of this research is to determine the prediction of absorption, distribution, metabolism,
and excretion (ADME) as well as the toxicity test of phthalimide-derived compounds which have the best
potential as HIV-1 reverse transcriptase enzyme inhibitors. This study used an in silico approach to predict
oral bioavailability and toxicity. The prediction of the ADME in this study using SwissADME which is run
online where thirty-three phthalimide derivate compounds have molecular weight, hydrogen donor and
acceptor bond, and log P that meet the criteria of Lipinski Rules. Prediction of toxicity in this study using
in silico method with Toxtree v1.60 and it is known that phthalimide derivate compounds are not
carcinogenic and mutagenic.
Creator
Tiara Ajeng Listyani, Fazlin Fauzi, Ariyanti, Tatiana Siska Wardani
Source
http://jurnal.globalhealthsciencegroup.com/index.php/PICNHS
Publisher
Global Health Science Group
Date
May 2022,
Contributor
PERI IRAWAN
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Citation
Tiara Ajeng Listyani, Fazlin Fauzi, Ariyanti, Tatiana Siska Wardani, “PROSIDING INTERNASIONAL Proceedings of the International Conference on Nursing and Health Sciences, Volume 3 No 1, May 2022
IN SILICO ADME AND TOXICITY STUDIES OF DERIVATIVE PHTHALIMIDE COMPOUNDS AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITOR,” Repository Horizon University Indonesia, accessed February 3, 2025, https://repository.horizon.ac.id/items/show/2935.
IN SILICO ADME AND TOXICITY STUDIES OF DERIVATIVE PHTHALIMIDE COMPOUNDS AS NON-NUCLEOSIDE HIV-1 REVERSE TRANSCRIPTASE INHIBITOR,” Repository Horizon University Indonesia, accessed February 3, 2025, https://repository.horizon.ac.id/items/show/2935.