Safety and Health at Work Vol. 14 Issue 3 2023
Association with Combined Occupational Hazards Exposure and Risk of Metabolic Syndrome: A Workers’ Health Examination Cohort 2012-2021 (Original article)
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Title
Safety and Health at Work Vol. 14 Issue 3 2023
Association with Combined Occupational Hazards Exposure and Risk of Metabolic Syndrome: A Workers’ Health Examination Cohort 2012-2021 (Original article)
Association with Combined Occupational Hazards Exposure and Risk of Metabolic Syndrome: A Workers’ Health Examination Cohort 2012-2021 (Original article)
Subject
Heavymetal exposure, Lifestyle disease, Occupational risk factors, Organic solvents exposure Worker’s health cohort
Description
Background: This study aimed to evaluate the association between exposure to occupational hazards and the metabolic syndrome. A secondary objective was to analyze the additive and multiplicative effects of exposure to risk factors.
Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios.
Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio 1⁄4 1.45: 95% confidence interval 1⁄4 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects.
Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.
Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios.
Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio 1⁄4 1.45: 95% confidence interval 1⁄4 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects.
Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.
Creator
Dongmug Kang , Eun-Soo Lee, Tae-Kyoung Kim, Yoon-Ji Kim, Seungho Lee, Woojoo Lee, Hyunman Sim, Se-Yeong Kim
Source
journal homepage: www.e-shaw.net
Publisher
Elsevier B.V. on behalf of Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency.
Date
21 August 2023
Contributor
Sri Wahyuni
Format
PDF
Language
English
Type
Text
Coverage
Safety and Health at Work Vol. 14 Issue 3 2023
Files
Citation
Dongmug Kang , Eun-Soo Lee, Tae-Kyoung Kim, Yoon-Ji Kim, Seungho Lee, Woojoo Lee, Hyunman Sim, Se-Yeong Kim, “Safety and Health at Work Vol. 14 Issue 3 2023
Association with Combined Occupational Hazards Exposure and Risk of Metabolic Syndrome: A Workers’ Health Examination Cohort 2012-2021 (Original article),” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/3451.
Association with Combined Occupational Hazards Exposure and Risk of Metabolic Syndrome: A Workers’ Health Examination Cohort 2012-2021 (Original article),” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/3451.