PROCEEDINGS 3nd INTERNATIONAL CONFERENCE ON HANDLING NON-COMMUNICABLE DISEASES (3ndICHNCDs) -A Web International Conference- 2021
Politeknik Kesehatan Kemenkes Semarang : “The Role of Health Care Providers on Handling Non-Communicable Disease Through Innovative Technology in the Research.”
THE EFFECT OF Pandanus conoideus Lamk EXTRACT TO THE PARASITEMIA RATE OF Plasmodium berghei INFECTED IN MICE

PROCEEDINGS 3nd INTERNATIONAL CONFERENCE ON HANDLING NON-COMMUNICABLE DISEASES (3ndICHNCDs) -A Web International Conference- 2021
Politeknik Kesehatan Kemenkes Semarang : “The Role of Health Care Providers on Handling Non-Communicable Disease Through Innovative Technology in the Research.”
THE EFFECT OF Pandanus conoideus Lamk EXTRACT TO THE PARASITEMIA RATE OF Plasmodium berghei INFECTED IN MICE

Red Fruit Extract (EBM); number of parasitemia; immunomodulator

Research on the effects of red fruit has been conducted with the various result. In this study, the effect of red fruit extract (EBM) on the level of parasitemia in swiss mice infected with Plasmodium berghei was well assessed. The study used a laboratory quasi-experimental design with pre and post-test-only control groups. Sixty male Swiss mice of 8 weeks old and weighing 20-30 g, was simply randomized into four treatment groups. Group I (K1) was stimulated with EBM for 2 weeks before and 2 weeks after infection with P.berghei. K2 was stimulated with EBM for 2 weeks before infection, K3 was stimulated with EBM for 2 weeks after infection and K4 is negative control was given 0.6% tween 40. The dose of EBM was 7.8 mg/30 g BW mice / PO once a day. The number of parasitemia was examined microscopically. The differences levels of parasitemia of each treatment group were analyzed by t-test, one-way ANOVA, and honestly significant difference (HSD), and also multivariate analysis (manova). There are significant differences number of parasitemia in the treatment group were stimulated with EBM for 2 weeks after infection, if compared with a negative control group, for day-6 is 13,735% and day-9 is 1,054%, and also to the treatment group was stimulated with EBM for 2 weeks before infection, which day-6 is 13,141% and day-9 is 32,455%. But negative control group shows, day-6 is 58,180 % and day-9 is 78,506%. The extract of red fruit can reduce the number of parasitemia. The effects of EBM are more significant, especially when administered after malaria infection occurred.

Blestina Maryorita; Zeth Roberth Felle; Guruh Suprayitno

Politeknik Kesehatan Kemenkes Semarang

23rd - 24th November 2021

Sri Wahyuni

ISBN: 978-623-5709-13-0

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English

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Prosiding Politeknik Kesehatan Kemenkes Semarang 2021