Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective bservational study
Dublin Core
Title
Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective bservational study
Subject
Sepsis, Acute respiratory distress syndrome, CD8+ T cell exhaustion, Coinhibitory receptors, Prognosis
Description
Background: CD8+ T cells are important for protective immunity against intracellular pathogens. Excessive amounts
of antigen and/or infammatory signals often lead to the gradual deterioration of CD8+ T cell function, a state called
“exhaustion”. However, the association between CD8+ T cell exhaustion and acute respiratory distress syndrome
(ARDS) has not been studied. This study was conducted to elucidate how CD8+ T cells and inhibitory receptors were
related to the clinical prognosis of ARDS.
Methods: A prospective observational study in an emergency department enrolled patients who were diagnosed
with sepsis-associated ARDS according to the sepsis-3 criteria and Berlin defnition. Peripheral blood samples were
collected within 24h post recruitment. CD8+ T cell count, proliferation ratio, cytokine secretion, and the expression of
coinhibitory receptors were assayed.
Results: Sixty-two patients with ARDS met the inclusion criteria. CD8+ T cell counts and proliferation rates were
dramatically decreased in non-surviving ARDS patients. Increasing programmed cell death 1 (PD-1) expression on the
CD8+ T cell surface was seen in patients with worse organ function, while an increasing level of T cell immunoglobulin mucin-3 (Tim-3) was associated with a longer duration of the shock. Kaplan–Meier analysis showed that low CD8+
T cell percentages and increased inhibitory molecule expression were signifcantly associated with a worse survival rate.
Conclusions: CD8+ T cells and coinhibitory receptors are promising independent prognostic markers of sepsisinduced ARDS, and increased CD8+ T cell exhaustion is signifcantly correlated with poor prognosis.
of antigen and/or infammatory signals often lead to the gradual deterioration of CD8+ T cell function, a state called
“exhaustion”. However, the association between CD8+ T cell exhaustion and acute respiratory distress syndrome
(ARDS) has not been studied. This study was conducted to elucidate how CD8+ T cells and inhibitory receptors were
related to the clinical prognosis of ARDS.
Methods: A prospective observational study in an emergency department enrolled patients who were diagnosed
with sepsis-associated ARDS according to the sepsis-3 criteria and Berlin defnition. Peripheral blood samples were
collected within 24h post recruitment. CD8+ T cell count, proliferation ratio, cytokine secretion, and the expression of
coinhibitory receptors were assayed.
Results: Sixty-two patients with ARDS met the inclusion criteria. CD8+ T cell counts and proliferation rates were
dramatically decreased in non-surviving ARDS patients. Increasing programmed cell death 1 (PD-1) expression on the
CD8+ T cell surface was seen in patients with worse organ function, while an increasing level of T cell immunoglobulin mucin-3 (Tim-3) was associated with a longer duration of the shock. Kaplan–Meier analysis showed that low CD8+
T cell percentages and increased inhibitory molecule expression were signifcantly associated with a worse survival rate.
Conclusions: CD8+ T cells and coinhibitory receptors are promising independent prognostic markers of sepsisinduced ARDS, and increased CD8+ T cell exhaustion is signifcantly correlated with poor prognosis.
Creator
Lei Yan, Yumei Chen, Yi Han and Chaoyang Tong
Publisher
BMC Emergency Medicine
Date
(2022) 22:182
Contributor
Fajar Bagus W
Format
PDF
Language
English
Type
Text
Files
Collection
Citation
Lei Yan, Yumei Chen, Yi Han and Chaoyang Tong, “Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective bservational study,” Repository Horizon University Indonesia, accessed September 20, 2024, https://repository.horizon.ac.id/items/show/4290.