The application of an age adjusted D-dimer threshold to rule out suspected venous thromboembolism (VTE) in an emergency department setting: a retrospective diagnostic cohort study
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Title
The application of an age adjusted D-dimer threshold to rule out suspected venous thromboembolism (VTE) in an emergency department setting: a retrospective diagnostic cohort study
Description
Background: Venous Thromboembolic disease (VTE) poses a diagnostic challenge for clinicians in acute care. Over
reliance on reference standard investigations can lead to over treatment and potential harm.
We sought to evaluate the pragmatic performance and implications of using an age adjusted D-dimer (AADD) strategy to rule out VTE in patients with suspected disease attending an emergency department (ED) setting. We aimed
to determine diagnostic test characteristics and assess whether this strategy would result in proportional imaging
reduction and potential cost savings.
Methods: Design: Single centre retrospective diagnostic cohort study.
All patients>50 years old evaluated for possible VTE who presented to the emergency department over a consecutive 12-month period between January and December 2016 with a positive D-dimer result. Clinical assessment
records and reference standard imaging results were followed up by multiple independent adjudicators and coded as
VTE positive or negative.
Results: During the study period, there were 2132 positive D-dimer results. One thousand two hundred thirty-six
patients received reference standard investigations. A total increase of 314/1236 (25.1%) results would have been
coded as true negatives as opposed to false positive if the AADD cut of point had been applied, with 314 reference
standard tests subsequently avoided. The AADD cut of had comparable sensitivity to the current cut of despite this
increase in specifcity; sensitivities for the diagnosis of DVT were 99.28% (95% CI 96.06–99.98%) and 97.72% for PE
(95% CI 91.94% to 97.72). There were 3 false negative results using the AADD strategy.
Conclusions: In patients with suspected VTE with a low or moderate pre-test probability, the application of AADD
appears to increase the proportion of patients in which VTE can be excluded without the need for reference standard
imaging. This management strategy is likely to be associated with substantial reduction in anticoagulation treatment,
investigations and cost/time savings.
reliance on reference standard investigations can lead to over treatment and potential harm.
We sought to evaluate the pragmatic performance and implications of using an age adjusted D-dimer (AADD) strategy to rule out VTE in patients with suspected disease attending an emergency department (ED) setting. We aimed
to determine diagnostic test characteristics and assess whether this strategy would result in proportional imaging
reduction and potential cost savings.
Methods: Design: Single centre retrospective diagnostic cohort study.
All patients>50 years old evaluated for possible VTE who presented to the emergency department over a consecutive 12-month period between January and December 2016 with a positive D-dimer result. Clinical assessment
records and reference standard imaging results were followed up by multiple independent adjudicators and coded as
VTE positive or negative.
Results: During the study period, there were 2132 positive D-dimer results. One thousand two hundred thirty-six
patients received reference standard investigations. A total increase of 314/1236 (25.1%) results would have been
coded as true negatives as opposed to false positive if the AADD cut of point had been applied, with 314 reference
standard tests subsequently avoided. The AADD cut of had comparable sensitivity to the current cut of despite this
increase in specifcity; sensitivities for the diagnosis of DVT were 99.28% (95% CI 96.06–99.98%) and 97.72% for PE
(95% CI 91.94% to 97.72). There were 3 false negative results using the AADD strategy.
Conclusions: In patients with suspected VTE with a low or moderate pre-test probability, the application of AADD
appears to increase the proportion of patients in which VTE can be excluded without the need for reference standard
imaging. This management strategy is likely to be associated with substantial reduction in anticoagulation treatment,
investigations and cost/time savings.
Creator
Liam Barrett , Tom Jones and Daniel Horner
Publisher
BMC Emergency Medicine
Date
(2022) 22:186
Contributor
Fajar bagus W
Format
PDF
Language
English
Type
Text
Files
Collection
Citation
Liam Barrett , Tom Jones and Daniel Horner, “The application of an age adjusted D-dimer threshold to rule out suspected venous thromboembolism (VTE) in an emergency department setting: a retrospective diagnostic cohort study,” Repository Horizon University Indonesia, accessed April 10, 2025, https://repository.horizon.ac.id/items/show/4312.