Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research)

Dublin Core

Title

Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research)

Subject

blood coagulation factors, COVID-19, patient outcome assessment

Description

BACKGROUND Causes of death and length of hospitalization in patients with COVID-19 have been associated with coagulopathy. The coagulopathy mechanism involves the process of coagulation and endothelial damage triggered by an inflammatory response of the SARS-CoV-2 infection due to excessive release of proinflammatory cytokines. This study aimed to determine the association of coagulation factors as potential predictors of COVID-19 patient outcomes.
METHODS This retrospective study was performed on 595 patients at Wahidin Sudirohusodo Hospital, Makassar, from June 2020 to June 2021. Participants were recruited using total sampling and assessed for COVID-19 severity using the World Health Organization classification and coagulation factors (D-dimer, fibrinogen, thrombocyte, and prothrombin time [PT]). Patient outcome assessments were survival and length of hospitalization.
RESULTS We found a significant sex-based disparity, with a higher COVID-19 incidence in males. Severe cases were more common among those aged >50 years, with prolonged hospitalization (>10 days) linked to higher severity (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.31–3.77, p<0.001). Elevated fibrinogen and D-dimer levels, as well as prolonged PT, predicted severe cases. However, D-dimer had the highest influence compared to other coagulation factors (OR = 14.50, 95% CI = 5.85–35.95, p<0.001), while prolonged PT influenced mortality rates (OR = 4.02, 95% CI = 1.35–12.00, p = 0.01).
CONCLUSIONS Coagulation factors, such as elevated D-dimer and fibrinogen levels and prolonged PT, predicted the severity of COVID-19 patients leading to death.

Creator

Dwi Anggita, Irawaty Djaharuddin, Harun Iskandar, Nur Ahmad Tabri, Jamaluddin Madolangan, Harry Akza Putrawan, Edward Pandu Wiriansya

Source

https://doi.org/10.13181/mji.oa.236992

Publisher

Fakultas Kedokteran Universitas Indonesia

Date

June 2023

Contributor

Sri Wahyuni

Rights

pISSN: 0853-1773 • eISSN: 2252-8083

Format

PDF

Language

English

Type

Text

Coverage

Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023

Files

Tags

,Repository, Repository Horizon University Indonesia, Repository Universitas Horizon Indonesia, Horizon.ac.id, Horizon University Indonesia, Universitas Horizon Indonesia, HorizonU, Repo Horizon , ,Repository, Repository Horizon University Indonesia, Repository Universitas Horizon Indonesia, Horizon.ac.id, Horizon University Indonesia, Universitas Horizon Indonesia, HorizonU, Repo Horizon , ,Repository, Repository Horizon University Indonesia, Repository Universitas Horizon Indonesia, Horizon.ac.id, Horizon University Indonesia, Universitas Horizon Indonesia, HorizonU, Repo Horizon ,

Citation

Dwi Anggita, Irawaty Djaharuddin, Harun Iskandar, Nur Ahmad Tabri, Jamaluddin Madolangan, Harry Akza Putrawan, Edward Pandu Wiriansya , “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research),” Repository Horizon University Indonesia, accessed November 10, 2024, https://repository.horizon.ac.id/items/show/4690.