Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research)
Dublin Core
Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research)
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research)
Subject
blood coagulation factors, COVID-19, patient outcome assessment
Description
BACKGROUND Causes of death and length of hospitalization in patients with COVID-19 have been associated with coagulopathy. The coagulopathy mechanism involves the process of coagulation and endothelial damage triggered by an inflammatory response of the SARS-CoV-2 infection due to excessive release of proinflammatory cytokines. This study aimed to determine the association of coagulation factors as potential predictors of COVID-19 patient outcomes.
METHODS This retrospective study was performed on 595 patients at Wahidin Sudirohusodo Hospital, Makassar, from June 2020 to June 2021. Participants were recruited using total sampling and assessed for COVID-19 severity using the World Health Organization classification and coagulation factors (D-dimer, fibrinogen, thrombocyte, and prothrombin time [PT]). Patient outcome assessments were survival and length of hospitalization.
RESULTS We found a significant sex-based disparity, with a higher COVID-19 incidence in males. Severe cases were more common among those aged >50 years, with prolonged hospitalization (>10 days) linked to higher severity (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.31–3.77, p<0.001). Elevated fibrinogen and D-dimer levels, as well as prolonged PT, predicted severe cases. However, D-dimer had the highest influence compared to other coagulation factors (OR = 14.50, 95% CI = 5.85–35.95, p<0.001), while prolonged PT influenced mortality rates (OR = 4.02, 95% CI = 1.35–12.00, p = 0.01).
CONCLUSIONS Coagulation factors, such as elevated D-dimer and fibrinogen levels and prolonged PT, predicted the severity of COVID-19 patients leading to death.
METHODS This retrospective study was performed on 595 patients at Wahidin Sudirohusodo Hospital, Makassar, from June 2020 to June 2021. Participants were recruited using total sampling and assessed for COVID-19 severity using the World Health Organization classification and coagulation factors (D-dimer, fibrinogen, thrombocyte, and prothrombin time [PT]). Patient outcome assessments were survival and length of hospitalization.
RESULTS We found a significant sex-based disparity, with a higher COVID-19 incidence in males. Severe cases were more common among those aged >50 years, with prolonged hospitalization (>10 days) linked to higher severity (odds ratio [OR] = 2.22, 95% confidence interval [CI] = 1.31–3.77, p<0.001). Elevated fibrinogen and D-dimer levels, as well as prolonged PT, predicted severe cases. However, D-dimer had the highest influence compared to other coagulation factors (OR = 14.50, 95% CI = 5.85–35.95, p<0.001), while prolonged PT influenced mortality rates (OR = 4.02, 95% CI = 1.35–12.00, p = 0.01).
CONCLUSIONS Coagulation factors, such as elevated D-dimer and fibrinogen levels and prolonged PT, predicted the severity of COVID-19 patients leading to death.
Creator
Dwi Anggita, Irawaty Djaharuddin, Harun Iskandar, Nur Ahmad Tabri, Jamaluddin Madolangan, Harry Akza Putrawan, Edward Pandu Wiriansya
Source
https://doi.org/10.13181/mji.oa.236992
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
June 2023
Contributor
Sri Wahyuni
Rights
pISSN: 0853-1773 • eISSN: 2252-8083
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Files
Citation
Dwi Anggita, Irawaty Djaharuddin, Harun Iskandar, Nur Ahmad Tabri, Jamaluddin Madolangan, Harry Akza Putrawan, Edward Pandu Wiriansya , “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 32 No. 2 2023
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research),” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/4690.
Coagulation factors as potential predictors of COVID-19 patient outcomes (Clinical Research),” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/4690.