AssocTests: An R Package for Genetic Association Studies

AssocTests: An R Package for Genetic Association Studies

distance regression, genetic association studies, population stratification, TracyWidom test, R

The R package AssocTests provides some procedures which are commonly used in
genetic association studies. These procedures are population stratification correction
through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance
regression, single-marker test, maximum test based on three Cochran-Armitage trend
tests, non-parametric trend test, and non-parametric maximum test. The trait values for
these methods should be discrete or continuous. The discrete traits can be coded by 1/0
for cases/controls. The genotype values can be 0, 1, or 2 indicating the number of risk
alleles for a biallelic single-nucleotide polymorphism. This article introduces the methods
and algorithms implemented in the package. Some examples are provided to illustrate
the package’s capability

Lin Wang

https://www.jstatsoft.org/article/view/v094i05

Capital University of
Economics and Business

June 2020

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