Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020
Neutrophil-to-Lymphocyte Ratio for Predictor of in-Hospital Mortality in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis
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Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020
Neutrophil-to-Lymphocyte Ratio for Predictor of in-Hospital Mortality in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis
Neutrophil-to-Lymphocyte Ratio for Predictor of in-Hospital Mortality in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis
Subject
in-hospital mortality, neutrophil-to-lymphocyte ratio, STEMI
Description
BACKGROUND ST-segment elevation myocardial infarction (STEMI) is the most life-threatening condition of acute coronary syndrome that carries a poor prognosis of in-hospital mortality. Multiple scoring systems have been developed to predict in-hospital mortality and other cardiovascular events. Neutrophil-to-lymphocyte ratio (NLR) is hardly used as a predictor of in-hospital mortality. This study was aimed to determine the predictive value of NLR concerning in-hospital mortality in STEMI patients.
METHODS Literature search and pooled analysis related to studies on MEDLINE/PubMed, EBSCO, Science Direct, Cochrane, and ProQuest were retrieved. Inclusion criteria were met if they were cohort studies, the subjects were STEMI patient,
contained pretreatment NLR cut-off, and considered in-hospital mortality, which is defined as cardiac or all-cause mortality. Quality assessment was conducted using Newcastle-Ottawa scale. Review Manager version 5.3 (The Nordic Cochrane Centre, Copenhagen) was used for meta-analysis.
RESULTS We found 12 studies with a total of 7,251 STEMI subjects with median NLR cutoff value of 5.6. Elevated NLR on admission carries a high risk of in-hospital mortality (odds ratio [OR] = 3.00, 95% confidence interval [CI] = 2.46–3.67). A slightly higher risk of all-cause mortality (OR = 2.74, 95% CI = 1.99–3.77) was observed compared with cardiac-related mortality (OR = 3.20, 95% CI = 2.47–4.14). No significant heterogeneity was observed between these studies (p = 0.46, I2 = 0%).
CONCLUSIONS Elevated NLR predicts a higher in-hospital mortality rate of STEMI patients.
METHODS Literature search and pooled analysis related to studies on MEDLINE/PubMed, EBSCO, Science Direct, Cochrane, and ProQuest were retrieved. Inclusion criteria were met if they were cohort studies, the subjects were STEMI patient,
contained pretreatment NLR cut-off, and considered in-hospital mortality, which is defined as cardiac or all-cause mortality. Quality assessment was conducted using Newcastle-Ottawa scale. Review Manager version 5.3 (The Nordic Cochrane Centre, Copenhagen) was used for meta-analysis.
RESULTS We found 12 studies with a total of 7,251 STEMI subjects with median NLR cutoff value of 5.6. Elevated NLR on admission carries a high risk of in-hospital mortality (odds ratio [OR] = 3.00, 95% confidence interval [CI] = 2.46–3.67). A slightly higher risk of all-cause mortality (OR = 2.74, 95% CI = 1.99–3.77) was observed compared with cardiac-related mortality (OR = 3.20, 95% CI = 2.47–4.14). No significant heterogeneity was observed between these studies (p = 0.46, I2 = 0%).
CONCLUSIONS Elevated NLR predicts a higher in-hospital mortality rate of STEMI patients.
Creator
Rodry Mikhael, Evan Hindoro, Sharleen Taner, Antonia Anna Lukito
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
2020-07-02
Contributor
Sri Wahyuni
Rights
ISSN : 0853-1773
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020
Files
Citation
Rodry Mikhael, Evan Hindoro, Sharleen Taner, Antonia Anna Lukito, “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 2 2020
Neutrophil-to-Lymphocyte Ratio for Predictor of in-Hospital Mortality in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis,” Repository Horizon University Indonesia, accessed October 14, 2024, https://repository.horizon.ac.id/items/show/850.
Neutrophil-to-Lymphocyte Ratio for Predictor of in-Hospital Mortality in ST-Segment Elevation Myocardial Infarction: A Meta-Analysis,” Repository Horizon University Indonesia, accessed October 14, 2024, https://repository.horizon.ac.id/items/show/850.