Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients
Dublin Core
Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients
Subject
liquid meal replacement nutrition, low glycemic index, type 2 diabetes mellitus
Description
BACKGROUND Liquid meal replacement nutrition (LMRN) contains low glycemic index food (isomaltulose, resistant dextrin, and inulin), which can decrease large blood glucose level fluctuations and reduce food intake. This study aimed to determine the stability of daily blood glucose and the level of appetite sensations after intake of
LMRN in type 2 diabetes mellitus (DM) patients.
METHODS This randomized, controlled, crossover, and open-labeled study included 30 subjects with type 2 DM. Subjects attended two visit sessions to consume either LMRN or controlled-nutrition solid food (CNSF) for 4 consecutive days. Each subject
had 2 days of 24-hour periods of blood glucose measurement using a continuous glucose monitoring system and had a 1-week washout period. Glycemic response (GR) and incremental area under the curve (iAUC) were calculated. The satiety level was measured using a visual analog scale.
RESULTS After 48 hours, LMRN reduced GR compared with CNSF with glucose measurements of 13.72 (30.42) and 17.47 (36.38) mg/dl, respectively. The reduction on iAUC after consuming LMRN (36,891 [30,255.8] mg.min/dl) compared with CNSF (40,641 [38,798.9] mg.min/dl) was also noted. Subjects having LMRN felt less hungry and more satiated than those consuming CNSF. The administration of LMRN does not
have any serious side effects.
CONCLUSIONS LMRN provides a greater reduction of GR and longer term of satiety compared with CNSF without causing any serious side effects.
LMRN in type 2 diabetes mellitus (DM) patients.
METHODS This randomized, controlled, crossover, and open-labeled study included 30 subjects with type 2 DM. Subjects attended two visit sessions to consume either LMRN or controlled-nutrition solid food (CNSF) for 4 consecutive days. Each subject
had 2 days of 24-hour periods of blood glucose measurement using a continuous glucose monitoring system and had a 1-week washout period. Glycemic response (GR) and incremental area under the curve (iAUC) were calculated. The satiety level was measured using a visual analog scale.
RESULTS After 48 hours, LMRN reduced GR compared with CNSF with glucose measurements of 13.72 (30.42) and 17.47 (36.38) mg/dl, respectively. The reduction on iAUC after consuming LMRN (36,891 [30,255.8] mg.min/dl) compared with CNSF (40,641 [38,798.9] mg.min/dl) was also noted. Subjects having LMRN felt less hungry and more satiated than those consuming CNSF. The administration of LMRN does not
have any serious side effects.
CONCLUSIONS LMRN provides a greater reduction of GR and longer term of satiety compared with CNSF without causing any serious side effects.
Creator
Fatimah Eliana, Budi Agung Pranoto
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
2020-10-05
Contributor
Sri Wahyuni
Rights
ISSN : 0853-1773
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020
Files
Citation
Fatimah Eliana, Budi Agung Pranoto, “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 3 2020
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients,” Repository Horizon University Indonesia, accessed October 14, 2024, https://repository.horizon.ac.id/items/show/888.
A Randomized Controlled Clinical Trial of Carbohydrate Mix-Fortified Nutrition in Type 2 Diabetes Mellitus Patients,” Repository Horizon University Indonesia, accessed October 14, 2024, https://repository.horizon.ac.id/items/show/888.