Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears
Dublin Core
Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears
A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears
Subject
amniotic membrane, interleukin-6, pterygium
Description
BACKGROUND Minimizing inflammation on the ocular surface after pterygium surgery is essential to prevent recurrence. Currently, limited data are available for the comparison between freeze-dried amniotic membrane (FD-AM) and conjunctival–
limbal graft (CLG). Therefore, this study aimed to assess conjunctival inflammation and the interleukin (IL)-6 levels in tears after pterygium excision between both techniques.
METHODS This prospective, single-blinded, randomized clinical trial included 26 eyes of 26 patients with primary or recurrent pterygium and who were indicated for pterygium surgery at Cipto Mangunkusumo Hospital, Indonesia from October 2017 until February 2018. The patients were scheduled for pterygium excision with FD-AM or CLG based on block randomization. Conjunctival inflammation and the level of IL-6 in tears were
measured on day-7 and -28 after surgery.
RESULTS The 26 eyes (13 in each group) were subjected to a complete 1-month followup period. Day-7 after the surgery, severe inflammation occurred in 4/13 (31%) eyes having FD-AM and 8/13 eyes (62%) having CLG (p = 0.59). The IL-6 tear level increased similarly in FD-AM (22.85 pg/ml) and CLG (23.51 pg/ml) in (p = 0.78). No severe adverse
events occurred.
CONCLUSIONS Pterygium excision using FD-AM yield a milder inflammation than CLG on day-7 and -28 after surgery. The tear IL-6 levels similarly increased on day-7.
limbal graft (CLG). Therefore, this study aimed to assess conjunctival inflammation and the interleukin (IL)-6 levels in tears after pterygium excision between both techniques.
METHODS This prospective, single-blinded, randomized clinical trial included 26 eyes of 26 patients with primary or recurrent pterygium and who were indicated for pterygium surgery at Cipto Mangunkusumo Hospital, Indonesia from October 2017 until February 2018. The patients were scheduled for pterygium excision with FD-AM or CLG based on block randomization. Conjunctival inflammation and the level of IL-6 in tears were
measured on day-7 and -28 after surgery.
RESULTS The 26 eyes (13 in each group) were subjected to a complete 1-month followup period. Day-7 after the surgery, severe inflammation occurred in 4/13 (31%) eyes having FD-AM and 8/13 eyes (62%) having CLG (p = 0.59). The IL-6 tear level increased similarly in FD-AM (22.85 pg/ml) and CLG (23.51 pg/ml) in (p = 0.78). No severe adverse
events occurred.
CONCLUSIONS Pterygium excision using FD-AM yield a milder inflammation than CLG on day-7 and -28 after surgery. The tear IL-6 levels similarly increased on day-7.
Creator
Made Susiyanti, Manoa Panjaitan, Grace Wangge, Tjahjono Darminto Gondhowiardjo
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
2021-01-01
Contributor
Sri Wahyuni
Rights
ISSN : 0853-1773
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Files
Citation
Made Susiyanti, Manoa Panjaitan, Grace Wangge, Tjahjono Darminto Gondhowiardjo, “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears,” Repository Horizon University Indonesia, accessed October 13, 2024, https://repository.horizon.ac.id/items/show/908.
A Randomized Clinical Trial of Freeze-Dried Amniotic Membrane Transplantation and Conjunctival-Limbal Graft for Pterygium Excision and Evaluation of Conjunctival Inflammation Marker in Tears,” Repository Horizon University Indonesia, accessed October 13, 2024, https://repository.horizon.ac.id/items/show/908.