JURNAL INTERNASIONAL KEBIDANAN 2020-2023 UNIVERSITAS KEDOKTERAN GUILAN VOLUME 32 ISSUE 3.
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Comparing the Effects of Paracetamol and Pethidine on First-stage Labor Pain Relief and Their Maternal and Neonatal Complications
Dublin Core
Title
JURNAL INTERNASIONAL KEBIDANAN 2020-2023 UNIVERSITAS KEDOKTERAN GUILAN VOLUME 32 ISSUE 3.
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Comparing the Effects of Paracetamol and Pethidine on First-stage Labor Pain Relief and Their Maternal and Neonatal Complications
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Comparing the Effects of Paracetamol and Pethidine on First-stage Labor Pain Relief and Their Maternal and Neonatal Complications
Subject
Labor pain, Paracetamol, Pethidine, Neonatal outcomes, Maternal outcomes
Description
Introduction: The pain relief effect of Paracetamol, as a safe analgesic drug in labor, compared
to Pethidine, as a well-known analgesic drug, need to be more evaluated.
Objective: This study aims to compare the effects of Paracetamol and Pethidine on the first-
stage labor pain relief and neonatal and maternal complications.
Materials and Methods: This single-blind, parallel group, randomized clinical trial conducted
on 100 nulliparous pregnant women referred to a maternity hospital in Rafsanjan Iran
in 2018 who were selected using a convenience sampling method and by assigned into
two groups Paracetamol (n=49, receiving 100 mg intravenous Paracetamol) and Pethidine
(n= 51, receiving 50 mg intravenous Pethidine) using the minimization method. The
drugs were administered when there was at least a 4-cm cervical dilation. Maternal
complications and infant’s 1 and 5-min the Apgar scores and ability to breastfeed were
evaluated. Pain intensity measured by the Visual Analogue Scale (VAS) and compared
using two-way repeated measures ANOVA before and 30 minutes, 1, 2, 3 and 4 hours
after drug administration.
Results: There were no significant differences between the two groups in term of age, body
mass index, and gestational age, and no significant difference in pain intensity in any groups
among the time points. Maternal complications were significantly lower in the Paracetamol
group than in the Pethidine group; however, the difference was statistically significant only in
terms of nausea (P=0.04). Infants’ breastfeeding ability was significantly better in Paracetamol
group than in the Pethidine group (P=0.04). The results of two-way ANOVA showed that the
mean VAS score was not significantly different between the two groups.
Conclusion: Paracetamol can alleviate the first-stage labor pain similar to Pethidine, but with
fewer maternal and neonatal complications.
to Pethidine, as a well-known analgesic drug, need to be more evaluated.
Objective: This study aims to compare the effects of Paracetamol and Pethidine on the first-
stage labor pain relief and neonatal and maternal complications.
Materials and Methods: This single-blind, parallel group, randomized clinical trial conducted
on 100 nulliparous pregnant women referred to a maternity hospital in Rafsanjan Iran
in 2018 who were selected using a convenience sampling method and by assigned into
two groups Paracetamol (n=49, receiving 100 mg intravenous Paracetamol) and Pethidine
(n= 51, receiving 50 mg intravenous Pethidine) using the minimization method. The
drugs were administered when there was at least a 4-cm cervical dilation. Maternal
complications and infant’s 1 and 5-min the Apgar scores and ability to breastfeed were
evaluated. Pain intensity measured by the Visual Analogue Scale (VAS) and compared
using two-way repeated measures ANOVA before and 30 minutes, 1, 2, 3 and 4 hours
after drug administration.
Results: There were no significant differences between the two groups in term of age, body
mass index, and gestational age, and no significant difference in pain intensity in any groups
among the time points. Maternal complications were significantly lower in the Paracetamol
group than in the Pethidine group; however, the difference was statistically significant only in
terms of nausea (P=0.04). Infants’ breastfeeding ability was significantly better in Paracetamol
group than in the Pethidine group (P=0.04). The results of two-way ANOVA showed that the
mean VAS score was not significantly different between the two groups.
Conclusion: Paracetamol can alleviate the first-stage labor pain similar to Pethidine, but with
fewer maternal and neonatal complications.
Creator
Masoumeh Khammar , Zohreh Ghorashi, Azita Manshoori
Date
July 2022, Volume 32, Number 3
Contributor
PERI IRAWAN
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Citation
Masoumeh Khammar , Zohreh Ghorashi, Azita Manshoori, “JURNAL INTERNASIONAL KEBIDANAN 2020-2023 UNIVERSITAS KEDOKTERAN GUILAN VOLUME 32 ISSUE 3.
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Comparing the Effects of Paracetamol and Pethidine on First-stage Labor Pain Relief and Their Maternal and Neonatal Complications,” Repository Horizon University Indonesia, accessed October 13, 2024, https://repository.horizon.ac.id/items/show/943.
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Comparing the Effects of Paracetamol and Pethidine on First-stage Labor Pain Relief and Their Maternal and Neonatal Complications,” Repository Horizon University Indonesia, accessed October 13, 2024, https://repository.horizon.ac.id/items/show/943.