JURNAL INTERNASIONAL KEBIDANAN 2020-2023 UNIVERSITAS KEDOKTERAN GUILAN VOLUME 32 ISSUE 4.
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Factors Associated With Medication Adherence in Coronary Artery Patients

JURNAL INTERNASIONAL KEBIDANAN 2020-2023 UNIVERSITAS KEDOKTERAN GUILAN VOLUME 32 ISSUE 4.
JOURNAL OF HOLISTIC NURSING OF MIDWIFERY.
Factors Associated With Medication Adherence in Coronary Artery Patients

Medication adherence, Coronary artery disease, Anxiety, Depression symptoms, stress

Introduction: Medication adherence plays an important role in preventing the worsening of
cardiovascular disease. Some factors associated with medication adherence are still unknown.
Objective: This study aimed to determine the factors related to medication adherence in
patients with coronary artery disease.
Materials and Methods: A cross-sectional analytical study was performed on 367
cardiovascular patients by consecutive sampling. The patients were referred to the
specialized cardiology clinic in Rasht City, Iran, from January 2019 to June 2020. A data
collection form and questionnaires of cardiac anxiety, anxiety depression and stress, and
medication adherence were used. The obtained data were analyzed by the Chi-square
test, Fisher exact test, Kolmogorov-Smirnov test, Mann-Whitney U test, and logistic
regression model. The significance level was considered less than 0.05.
Results: Most samples were men (61.85%). The Mean±SD age of the samples was 59.9±10.9
years. About 20.7% had high adherence, and 78.75% had moderate adherence. Factors
related to medication adherence included employment or being retired (OR=4.0, 95%CI;
1-16.6, P=0.054), income level (OR= 5.1, 95%CI; 1.6-16.6, P=0.007), supplemental insurance
(OR= 0.217, 95%CI; 0.07-0.66, P=0.007), living alone (OR= 10.187, 95%CI;1.980-52.404,
P=0.005), living with spouse and children (OR= 3.776, 95%CI; 1.580-9.023, P=0.054), history
of hyperlipidemia (OR= 3.2, 95%CI; 1.2-8.4, P=0.019), history of stent implantation (OR= 2.9
95%CI; 1.2-7, P=0.016), depression (OR=0.74, 95%CI; 0.66-0.83, P=0.0001), anxiety (OR= 1.3,
95%CI; 1.1-1.4, P=0.0001), avoidance (OR=0.69, 95%CI; 0.56-0.86, P=0.0001), attention (OR=
1.5, 95%CI; 1.2-1.8, P=0.0001), and medication complexity (OR= 2.7, 95%CI; 1-6.8, P=0.04).
Conclusion: According to the identified related factors, it may be possible to decline
anxiety and depression symptoms by improving the related factors and follow-up of care
programs. As a result, cardiovascular patients are helped by preventing readmission,
cardiac event, and mortality.

Shiva Mashouf Rad , Mohammad Taghi Moghadamnia , Ehsan Kazemnezhad Leili , Nazila Javadi-Pashaki

October 2022, Volume 32, Number 4

PERI IRAWAN

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