Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management
Dublin Core
Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management
Subject
COVID-19, free radicals, uric acid, xanthine oxidase
Description
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally,
including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.
including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.
Creator
Irandi Putra Pratomo, Anna Ariane, Aryo Tedjo, Rudi Heryanto, Rafika Indah Paramita
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
2021-03-31
Contributor
Sri Wahyuni
Rights
ISSN : 0853-1773
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021
Files
Citation
Irandi Putra Pratomo, Anna Ariane, Aryo Tedjo, Rudi Heryanto, Rafika Indah Paramita, “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 30 No. 1 2021
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management,” Repository Horizon University Indonesia, accessed October 31, 2025, https://repository.horizon.ac.id/items/show/966.
Xanthine Oxidase Inhibition in SARS-CoV-2 Infection: The Mechanism and Potency of Allopurinol and Febuxostat in COVID-19 Management,” Repository Horizon University Indonesia, accessed October 31, 2025, https://repository.horizon.ac.id/items/show/966.