Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Association of P-Glycoprotein Expression and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Dublin Core
Title
Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Association of P-Glycoprotein Expression and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Clinical Research Association of P-Glycoprotein Expression and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Subject
breast cancer, neoadjuvant chemotherapy, p-glycoprotein, treatment
outcome
outcome
Description
BACKGROUND Neoadjuvant chemotherapy (NACT) has been shown to improve the
overall survival of locally advanced breast cancer (LABC) patients with pathological
complete response. However, the efficacy may be reduced due to chemoresistance
mediated by P-glycoprotein (Pgp). This study aimed to explore the association between
Pgp expression and patients’ response to NACT.
METHODS A prospective cohort study was carried out from May 2018 to October 2019
at Cipto Mangunkusumo Hospital and Koja Hospital. Treatment-naïve LABC patients
were consecutively enrolled in the study. Immunohistochemistry analysis of the biopsy
samples was done to semi-quantitatively measure Pgp expression. The clinical response
was evaluated after 3 cycles of NACT, while the pathological response was evaluated
for subjects who underwent surgery post-NACT.
RESULTS Mean age of the subjects was 46.2 (9.6) years old, and most of the cases were
invasive ductal (78%) and luminal B subtype (61%). Pgp was strongly expressed in 21/27
subjects (78%). There were no differences between Pgp-positive and -negative subjects
for clinical response (relative risk [RR] 1.1, 95% confidence interval [CI] 0.33–4.01, p =
0.61) and pathological response (RR 1.3, 95% CI 0.8–1.9, p = 0.22). Other clinicopathologic
variables were not associated with either clinical or pathological responses.
CONCLUSIONS These results showed that Pgp is expressed in most LABC patients, but
its role as a predictive factor could not be established. However, due to the limited
subjects and a lack of standardized Pgp measurement,
overall survival of locally advanced breast cancer (LABC) patients with pathological
complete response. However, the efficacy may be reduced due to chemoresistance
mediated by P-glycoprotein (Pgp). This study aimed to explore the association between
Pgp expression and patients’ response to NACT.
METHODS A prospective cohort study was carried out from May 2018 to October 2019
at Cipto Mangunkusumo Hospital and Koja Hospital. Treatment-naïve LABC patients
were consecutively enrolled in the study. Immunohistochemistry analysis of the biopsy
samples was done to semi-quantitatively measure Pgp expression. The clinical response
was evaluated after 3 cycles of NACT, while the pathological response was evaluated
for subjects who underwent surgery post-NACT.
RESULTS Mean age of the subjects was 46.2 (9.6) years old, and most of the cases were
invasive ductal (78%) and luminal B subtype (61%). Pgp was strongly expressed in 21/27
subjects (78%). There were no differences between Pgp-positive and -negative subjects
for clinical response (relative risk [RR] 1.1, 95% confidence interval [CI] 0.33–4.01, p =
0.61) and pathological response (RR 1.3, 95% CI 0.8–1.9, p = 0.22). Other clinicopathologic
variables were not associated with either clinical or pathological responses.
CONCLUSIONS These results showed that Pgp is expressed in most LABC patients, but
its role as a predictive factor could not be established. However, due to the limited
subjects and a lack of standardized Pgp measurement,
Creator
Erwin Danil Yulian, Filipus Dasawala, Nurjati Chairani Siregar
Source
https://doi.org/10.13181/mji.oa.225863
Date
April 09, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Erwin Danil Yulian, Filipus Dasawala, Nurjati Chairani Siregar, “Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Association of P-Glycoprotein Expression and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer,” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1040.
Clinical Research Association of P-Glycoprotein Expression and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer,” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1040.