Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Procalcitonin Prognostic Value in Predicting Mortality among Adult Patients with Sepsis due to Gram-Negative Bacteria

Medical Journal of Indonesia Vol. 31 No. 1 2022 FKUI
Clinical Research Procalcitonin Prognostic Value in Predicting Mortality among Adult Patients with Sepsis due to Gram-Negative Bacteria

bacteremia, mortality, procalcitonin, sepsis

BACKGROUND Sepsis is a leading cause of mortality and morbidity globally. Gram-
negative bacteremia was reported to have a high risk of septic shock and poor

prognosis. This study aimed to evaluate the role of procalcitonin in predicting mortality
in patients with sepsis due to Gram-negative bacteria.
METHODS This was a retrospective cohort study performed based on medical records
and sepsis registry of Tropical and Infectious Disease Division, Department of Internal
Medicine, Cipto Mangunkusumo Hospital. The inclusion criteria were patients aged ≥18
years diagnosed with sepsis due to Gram-negative bacteria based on blood culture on
admission and hospitalized between March 2017 and October 2020. Data taken from
medical records included subjects’ characteristics, laboratory parameters, and 28-day
mortality outcomes during hospitalization. Receiver operating characteristic was used
to determine the area under the curve (AUC) of procalcitonin and its accuracy.
RESULTS A total of 128 patients were eligible. The cumulative survival of patients with
Gram-negative bacteremia was 48.4% (standard error 0.96%). The AUC of procalcitonin
to predict mortality was 0.45 (95% confidence interval 0.36–0.54). Escherichia coli was
the predominant microorganism in blood culture (n = 38, 29.7%).
CONCLUSIONS Procalcitonin has a poor performance in predicting mortality of patients
with sepsis due to Gram-negative bacteria.
KEYWORDS bacteremia, mortality, procalcitonin, sepsis

Bonita Effendi, Ceva Wicaksono Pitoyo, Robert Sinto, Suhendro Suwarto

thn 2022

peri irawan

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