Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Efficacy and Side Effects of Blacksoap® as Adjuvant Therapy of Scabies: A Randomized Control Trial
Dublin Core
Title
Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Efficacy and Side Effects of Blacksoap® as Adjuvant Therapy of Scabies: A Randomized Control Trial
Clinical Research Efficacy and Side Effects of Blacksoap® as Adjuvant Therapy of Scabies: A Randomized Control Trial
Subject
adverse effects, Blacksoap®, itching, mange
Description
BACKGROUND Blacksoap® is recognized as adjuvant therapy for scabies, but there has
been no significant study on its effectiveness. This study aimed to compare the efficacy
and safety between Blacksoap® and placebo on standard treatment for pruritus visual
analog scale (VAS) and transepidermal water loss (TEWL) scores before and after
receiving therapy.
METHODS This single-blind randomized controlled trial was held in a boarding school in
West Java in 2018. Subjects were recruited consecutively by random cluster sampling.
Both groups received standard permethrin 5% cream therapy. The intervention group
(n = 37) obtained Blacksoap®, while the control (n = 41) received baby soap. During the
initial assessment, pruritus VAS and TEWL scores were taken. The cure rate, scores of
pruritus VAS and TEWL, as well as side effects were assessed and compared during the
first and fourth weeks. Data were analyzed using SPSS software version 20 (IBM Corp.,
USA) by a third party, mostly using non-parametric tests.
RESULTS The cure rate of the intervention group was lower than the control in the first
week with 75% versus 81% but higher in the fourth week with 97% versus 92%. There was
no significant difference in the scores of pruritus VAS and TEWL, as well as side effects
between the two groups.
CONCLUSIONS The efficacy and safety of scabies treatment were similar between
Blacksoap® and placebo adjunctive to standard treatment. Blacksoap®, on top of
standard scabies treatment, might benefit patients by providing a higher cure rate in 4
weeks without any considerable adverse effects.
been no significant study on its effectiveness. This study aimed to compare the efficacy
and safety between Blacksoap® and placebo on standard treatment for pruritus visual
analog scale (VAS) and transepidermal water loss (TEWL) scores before and after
receiving therapy.
METHODS This single-blind randomized controlled trial was held in a boarding school in
West Java in 2018. Subjects were recruited consecutively by random cluster sampling.
Both groups received standard permethrin 5% cream therapy. The intervention group
(n = 37) obtained Blacksoap®, while the control (n = 41) received baby soap. During the
initial assessment, pruritus VAS and TEWL scores were taken. The cure rate, scores of
pruritus VAS and TEWL, as well as side effects were assessed and compared during the
first and fourth weeks. Data were analyzed using SPSS software version 20 (IBM Corp.,
USA) by a third party, mostly using non-parametric tests.
RESULTS The cure rate of the intervention group was lower than the control in the first
week with 75% versus 81% but higher in the fourth week with 97% versus 92%. There was
no significant difference in the scores of pruritus VAS and TEWL, as well as side effects
between the two groups.
CONCLUSIONS The efficacy and safety of scabies treatment were similar between
Blacksoap® and placebo adjunctive to standard treatment. Blacksoap®, on top of
standard scabies treatment, might benefit patients by providing a higher cure rate in 4
weeks without any considerable adverse effects.
Creator
Lidwina Anissa, Wresti Indriatmi, Larisa Paramitha Wibawa, Sandra Widaty
Date
June 18, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
txet
Files
Citation
Lidwina Anissa, Wresti Indriatmi, Larisa Paramitha Wibawa, Sandra Widaty, “Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Efficacy and Side Effects of Blacksoap® as Adjuvant Therapy of Scabies: A Randomized Control Trial,” Repository Horizon University Indonesia, accessed April 3, 2025, https://repository.horizon.ac.id/items/show/1053.
Clinical Research Efficacy and Side Effects of Blacksoap® as Adjuvant Therapy of Scabies: A Randomized Control Trial,” Repository Horizon University Indonesia, accessed April 3, 2025, https://repository.horizon.ac.id/items/show/1053.