Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Thromboelastographic Method for Early Decision on Anticoagulant Therapy in Moderate to Severe COVID-19 Patients
Dublin Core
Title
Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Thromboelastographic Method for Early Decision on Anticoagulant Therapy in Moderate to Severe COVID-19 Patients
Clinical Research Thromboelastographic Method for Early Decision on Anticoagulant Therapy in Moderate to Severe COVID-19 Patients
Subject
blood coagulation disorder, COVID-19, intensive care unit, mortality,
thromboelastography
thromboelastography
Description
BACKGROUND Coagulopathy is a serious COVID-19 complication that requires rapid
diagnosis and anticoagulation. This study aimed to determine the role of coagulation
examination using thromboelastography (TEG) on the decision-making time of
anticoagulant therapy in COVID-19 patients and its clinical outcomes.
METHODS A prospective observational study was conducted in Cipto Mangunkusumo
Hospital, Indonesia, from October 2020 to March 2021. We consecutively recruited
moderate and severe COVID-19 patients in the high and intensive care units. Turnaround
time, time to anticoagulant therapy decision, and clinical outcomes (length of stay
and 30-day mortality) were compared between those who had a TEG examination in
addition to the standard coagulation profile examination (thrombocyte count, PT,
APTT, D-dimer, and fibrinogen) and those who had only a standard coagulation profile
laboratory examination.
RESULTS Among 100 moderate to severe COVID-19 patients recruited, 50 patients had
a TEG examination. The turnaround time of TEG was 45 (15–102) min versus 82 (19–
164) min in the standard examination (p<0.001). The time to decision was significantly
faster in the TEG group than the standard group (75 [42–133] min versus 184 [92–353]
min, p<0.001). The turnaround time was positively correlated with time to decision (r =
0.760, p<0.001). However, TEG did not improve clinical outcomes such as length of stay
(10.5 [3–20] versus 9 [2–39] days) and 30-day mortality (66% versus 64%).
CONCLUSIONS The TEG method significantly enables quicker decision-making time for
moderate to severe coagulation disorder in COVID-19 patients.
diagnosis and anticoagulation. This study aimed to determine the role of coagulation
examination using thromboelastography (TEG) on the decision-making time of
anticoagulant therapy in COVID-19 patients and its clinical outcomes.
METHODS A prospective observational study was conducted in Cipto Mangunkusumo
Hospital, Indonesia, from October 2020 to March 2021. We consecutively recruited
moderate and severe COVID-19 patients in the high and intensive care units. Turnaround
time, time to anticoagulant therapy decision, and clinical outcomes (length of stay
and 30-day mortality) were compared between those who had a TEG examination in
addition to the standard coagulation profile examination (thrombocyte count, PT,
APTT, D-dimer, and fibrinogen) and those who had only a standard coagulation profile
laboratory examination.
RESULTS Among 100 moderate to severe COVID-19 patients recruited, 50 patients had
a TEG examination. The turnaround time of TEG was 45 (15–102) min versus 82 (19–
164) min in the standard examination (p<0.001). The time to decision was significantly
faster in the TEG group than the standard group (75 [42–133] min versus 184 [92–353]
min, p<0.001). The turnaround time was positively correlated with time to decision (r =
0.760, p<0.001). However, TEG did not improve clinical outcomes such as length of stay
(10.5 [3–20] versus 9 [2–39] days) and 30-day mortality (66% versus 64%).
CONCLUSIONS The TEG method significantly enables quicker decision-making time for
moderate to severe coagulation disorder in COVID-19 patients.
Creator
Komang Ayu Ferdiana, Andi Ade Wijaya Ramlan, Ratna Farida Soenarto, Anas Alatas
Date
June 01, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Komang Ayu Ferdiana, Andi Ade Wijaya Ramlan, Ratna Farida Soenarto, Anas Alatas, “Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Thromboelastographic Method for Early Decision on Anticoagulant Therapy in Moderate to Severe COVID-19 Patients,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/1054.
Clinical Research Thromboelastographic Method for Early Decision on Anticoagulant Therapy in Moderate to Severe COVID-19 Patients,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/1054.