Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Intravenous Magnesium Sulfate versus Intravenous Meperidine to Prevent Shivering during Spinal Anesthesia
Dublin Core
Title
Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Intravenous Magnesium Sulfate versus Intravenous Meperidine to Prevent Shivering during Spinal Anesthesia
Clinical Research Intravenous Magnesium Sulfate versus Intravenous Meperidine to Prevent Shivering during Spinal Anesthesia
Subject
magnesium sulfate, meperidine, shivering, spinal anesthesia
Description
BACKGROUND Shivering is a frequent event during neuraxial anesthesia due to
impaired central and peripheral thermoregulation control. Meperidine and MgSO4
are
effective in lowering the shivering threshold. Hence, this study aimed to compare the
efficacy of MgSO4
and meperidine to prevent shivering in patients undergoing spinal
anesthesia.
METHODS This was a double-blind randomized clinical trial of 100 patients divided into 2
groups. One group had MgSO4
30 mg/kg, and the other group had meperidine 0.5 mg/kg
intravenously in 100 ml of 0.9% NaCl before undergoing spinal anesthesia. Participants
were non-pregnant patients aged 18–65 years and had physical status I or II (based
on the American Society of Anesthesiologist). Shivering was considered significant if it
occurred in grade 3 or 4. Patient characteristics, shivering degree, tympanic membrane
temperature, and side effects were recorded.
RESULTS Shivering occurred 10% in the MgSO4
group and 19% in the meperidine group,
with p = 0.23. Both groups had similar side effects of nausea, vomiting, and hypotension.
CONCLUSIONS MgSO4
30 mg/kg was not superior to meperidine 0.5 mg/kg intravenously
in preventing shivering in patients undergoing spinal anesthesia.
impaired central and peripheral thermoregulation control. Meperidine and MgSO4
are
effective in lowering the shivering threshold. Hence, this study aimed to compare the
efficacy of MgSO4
and meperidine to prevent shivering in patients undergoing spinal
anesthesia.
METHODS This was a double-blind randomized clinical trial of 100 patients divided into 2
groups. One group had MgSO4
30 mg/kg, and the other group had meperidine 0.5 mg/kg
intravenously in 100 ml of 0.9% NaCl before undergoing spinal anesthesia. Participants
were non-pregnant patients aged 18–65 years and had physical status I or II (based
on the American Society of Anesthesiologist). Shivering was considered significant if it
occurred in grade 3 or 4. Patient characteristics, shivering degree, tympanic membrane
temperature, and side effects were recorded.
RESULTS Shivering occurred 10% in the MgSO4
group and 19% in the meperidine group,
with p = 0.23. Both groups had similar side effects of nausea, vomiting, and hypotension.
CONCLUSIONS MgSO4
30 mg/kg was not superior to meperidine 0.5 mg/kg intravenously
in preventing shivering in patients undergoing spinal anesthesia.
Creator
Pryambodho, Sidharta Kusuma Manggala, Magdalena Sihombing
Source
https://doi.org/10.13181/mji.oa.225886
Date
June 06, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Pryambodho, Sidharta Kusuma Manggala, Magdalena Sihombing, “Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Intravenous Magnesium Sulfate versus Intravenous Meperidine to Prevent Shivering during Spinal Anesthesia,” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1055.
Clinical Research Intravenous Magnesium Sulfate versus Intravenous Meperidine to Prevent Shivering during Spinal Anesthesia,” Repository Horizon University Indonesia, accessed February 5, 2025, https://repository.horizon.ac.id/items/show/1055.