Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Kidney Function Profile before, during, and after Ramadan Fasting in Healthy Elderly: A Prospective Cohort Study
Dublin Core
Title
Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Kidney Function Profile before, during, and after Ramadan Fasting in Healthy Elderly: A Prospective Cohort Study
Clinical Research Kidney Function Profile before, during, and after Ramadan Fasting in Healthy Elderly: A Prospective Cohort Study
Subject
elderly, fasting, glomerular filtration rate, Islam
Description
BACKGROUND Kidney function profile is one of the important parameters in
determining the health of the elderly. In Indonesia, no study has been conducted on
kidney function profile during Ramadan fasting to determine the safety of Ramadan
fasting in the elderly. This study aimed to determine the kidney function profile in the
elderly who fasted during Ramadan.
METHODS This study used a prospective cohort design. The inclusion criteria were
elderly aged >60 years undergoing Ramadan fasting in Jatinegara, Jakarta from
April to July 2019. Patients with end-stage renal failure who had an acute infection,
hypertension crisis, or refused to participate in the study were excluded. Patients who
did not fast for 3 consecutive days were dropped out. The kidney function profile was
calculated by the estimated glomerular filtration rate (eGFR) using the CKD-EPI formula
1 week before the first day of Ramadan, 3 weeks after the first day of fasting, and 2
weeks after the last day of fasting. Decreased eGFR was defined as having a minimum
of 20% eGFR decline during or after the fasting period. Bivariate analysis was performed
using McNemar or Cochran tests.
RESULTS 2 patients had eGFR decline during fasting, and 7 patients had eGFR decline
after fasting. The median eGFR before, during, and after fasting were 81.5, 88.7, and
76.8 ml/min/1.73 m2, respectively. A total of 1.4% of subjects had decreased eGFR during
Ramadan, while 9.1% had decreased eGFR after Ramadan. However, the changes were
not statistically significant.
CONCLUSIONS Although most elderly had lower eGFR following Ramadan fasting
compared to before and during Ramadan, only individuals with several comorbidities
had significant changes of kidney function.
determining the health of the elderly. In Indonesia, no study has been conducted on
kidney function profile during Ramadan fasting to determine the safety of Ramadan
fasting in the elderly. This study aimed to determine the kidney function profile in the
elderly who fasted during Ramadan.
METHODS This study used a prospective cohort design. The inclusion criteria were
elderly aged >60 years undergoing Ramadan fasting in Jatinegara, Jakarta from
April to July 2019. Patients with end-stage renal failure who had an acute infection,
hypertension crisis, or refused to participate in the study were excluded. Patients who
did not fast for 3 consecutive days were dropped out. The kidney function profile was
calculated by the estimated glomerular filtration rate (eGFR) using the CKD-EPI formula
1 week before the first day of Ramadan, 3 weeks after the first day of fasting, and 2
weeks after the last day of fasting. Decreased eGFR was defined as having a minimum
of 20% eGFR decline during or after the fasting period. Bivariate analysis was performed
using McNemar or Cochran tests.
RESULTS 2 patients had eGFR decline during fasting, and 7 patients had eGFR decline
after fasting. The median eGFR before, during, and after fasting were 81.5, 88.7, and
76.8 ml/min/1.73 m2, respectively. A total of 1.4% of subjects had decreased eGFR during
Ramadan, while 9.1% had decreased eGFR after Ramadan. However, the changes were
not statistically significant.
CONCLUSIONS Although most elderly had lower eGFR following Ramadan fasting
compared to before and during Ramadan, only individuals with several comorbidities
had significant changes of kidney function.
Creator
Murdani Abdullah, Edy Rizal Wahyudi, Pringgodigdo Nugroho, Andi Alfian
Date
July 02, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Murdani Abdullah, Edy Rizal Wahyudi, Pringgodigdo Nugroho, Andi Alfian, “Medical Journal of Indonesia Vol. 31 No. 2 2022 FKUI
Clinical Research Kidney Function Profile before, during, and after Ramadan Fasting in Healthy Elderly: A Prospective Cohort Study,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/1058.
Clinical Research Kidney Function Profile before, during, and after Ramadan Fasting in Healthy Elderly: A Prospective Cohort Study,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/1058.