Medical Journal of Indonesia Vol. 31 No. 3 2022 FKUI
RAGE and HMGB1 Expressions in Fetal Membranes of Premature Rupture of Membranes Patients
Dublin Core
Title
Medical Journal of Indonesia Vol. 31 No. 3 2022 FKUI
RAGE and HMGB1 Expressions in Fetal Membranes of Premature Rupture of Membranes Patients
RAGE and HMGB1 Expressions in Fetal Membranes of Premature Rupture of Membranes Patients
Subject
fetal membranes, high mobility group box protein 1 , immunohistochemistry,
premature rupture of membranes, receptor for advanced glycation end products
premature rupture of membranes, receptor for advanced glycation end products
Description
Premature rupture of membranes (PROM) is
defined as a spontaneous rupture of membranes any
time after the 28th week of pregnancy but before the
onset of labor. It occurs in 5–10% of all pregnancies,
contributing to 30–40% of preterm labor cases (15
million cases per year),1
which increases mortality and
morbidity for mother, fetus, and neonate.2,3 PROM
arises from complex, multifaceted pathophysiologic
pathways where the inflammation axis plays a crucial
role.4
Recently, an increasing number of studies have
shown the implication of sterile inflammation in
the fetal membrane weakening of PROM.5,6 This
concept is dependent on specific molecules called
alarmins or damage-associated molecular patterns
(DAMP), which are released and recognized by
pattern recognition receptors (PRRs), leading to a
microbial-free inflammatory response or a sterile
inflammation.1
High-mobility group box 1 (HMGB1),
which is a nuclear protein, is a DAMP molecule
defined as a spontaneous rupture of membranes any
time after the 28th week of pregnancy but before the
onset of labor. It occurs in 5–10% of all pregnancies,
contributing to 30–40% of preterm labor cases (15
million cases per year),1
which increases mortality and
morbidity for mother, fetus, and neonate.2,3 PROM
arises from complex, multifaceted pathophysiologic
pathways where the inflammation axis plays a crucial
role.4
Recently, an increasing number of studies have
shown the implication of sterile inflammation in
the fetal membrane weakening of PROM.5,6 This
concept is dependent on specific molecules called
alarmins or damage-associated molecular patterns
(DAMP), which are released and recognized by
pattern recognition receptors (PRRs), leading to a
microbial-free inflammatory response or a sterile
inflammation.1
High-mobility group box 1 (HMGB1),
which is a nuclear protein, is a DAMP molecule
Creator
Ketut Edy Sudiarta, Cindy Jennilyn Candra, Joan Khan, Rahadianto, Fitri Handajani
Source
https://doi.org/10.13181/mji.oa.226099
Date
August 24, 2022
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Ketut Edy Sudiarta, Cindy Jennilyn Candra, Joan Khan, Rahadianto, Fitri Handajani , “Medical Journal of Indonesia Vol. 31 No. 3 2022 FKUI
RAGE and HMGB1 Expressions in Fetal Membranes of Premature Rupture of Membranes Patients,” Repository Horizon University Indonesia, accessed October 31, 2025, https://repository.horizon.ac.id/items/show/1073.
RAGE and HMGB1 Expressions in Fetal Membranes of Premature Rupture of Membranes Patients,” Repository Horizon University Indonesia, accessed October 31, 2025, https://repository.horizon.ac.id/items/show/1073.