Medical Journal of Indonesia Vol. 31 No. 4 2022 FKUI
Pancreatoblastoma in Previously Pancreatic Pseudocysts in a 14-Year-Old Female: A Case Report
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Title
Medical Journal of Indonesia Vol. 31 No. 4 2022 FKUI
Pancreatoblastoma in Previously Pancreatic Pseudocysts in a 14-Year-Old Female: A Case Report
Pancreatoblastoma in Previously Pancreatic Pseudocysts in a 14-Year-Old Female: A Case Report
Subject
pancreas, pancreatic neoplasm, pancreatic pseudocysts,
pancreatoblastoma
pancreatoblastoma
Description
Pancreatoblastoma is a rare tumor characterized by uncontrolled growth of pancreatic
epithelial cells with a mix of squamous nests and acinar differentiation. Diagnostic
modalities include abnormal liver enzyme, pancreatic enzyme, and imaging findings.
Treatment options include surgical resection, sometimes combined with chemotherapy,
depending on the tumor’s size and grade. We reported a pancreatoblastoma in
a 14-year-old female with prior pancreatic pseudocysts. The transformation from
pseudocysts to pancreatoblastoma is believed to be caused by the heterozygosity
molecular loss on the 11p chromosome and several genetic mutations. Magnetic
resonance cholangiopancreatography showed a well-defined, heterogeneous mass in
the pancreatic head, with 70% of the mass composed of cysts. A partial pancreatectomy
was performed because a complete pancreatectomy may harm the adjacent structures.
However, a complete resection combined with chemoradiation may be the best option
for long-term survival and complete remission. In this case, she was disease-free until
30 months after the chemotherapy protocol.
epithelial cells with a mix of squamous nests and acinar differentiation. Diagnostic
modalities include abnormal liver enzyme, pancreatic enzyme, and imaging findings.
Treatment options include surgical resection, sometimes combined with chemotherapy,
depending on the tumor’s size and grade. We reported a pancreatoblastoma in
a 14-year-old female with prior pancreatic pseudocysts. The transformation from
pseudocysts to pancreatoblastoma is believed to be caused by the heterozygosity
molecular loss on the 11p chromosome and several genetic mutations. Magnetic
resonance cholangiopancreatography showed a well-defined, heterogeneous mass in
the pancreatic head, with 70% of the mass composed of cysts. A partial pancreatectomy
was performed because a complete pancreatectomy may harm the adjacent structures.
However, a complete resection combined with chemoradiation may be the best option
for long-term survival and complete remission. In this case, she was disease-free until
30 months after the chemotherapy protocol.
Creator
Monica Bellynda, Marsih, Yohanes Adinugroho, Suwardi, Muhammad Riza, Faizal Muhammad
Source
https://doi.org/10.13181/mji.cr.236351
Date
February 13, 2023
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Citation
Monica Bellynda, Marsih, Yohanes Adinugroho, Suwardi, Muhammad Riza, Faizal Muhammad, “Medical Journal of Indonesia Vol. 31 No. 4 2022 FKUI
Pancreatoblastoma in Previously Pancreatic Pseudocysts in a 14-Year-Old Female: A Case Report,” Repository Horizon University Indonesia, accessed February 6, 2025, https://repository.horizon.ac.id/items/show/1090.
Pancreatoblastoma in Previously Pancreatic Pseudocysts in a 14-Year-Old Female: A Case Report,” Repository Horizon University Indonesia, accessed February 6, 2025, https://repository.horizon.ac.id/items/show/1090.