Mitigating chemotherapy-induced oral mucositis: a comparative trial of cryotherapy and normal saline
Dublin Core
Title
Mitigating chemotherapy-induced oral mucositis: a comparative trial of cryotherapy and normal saline
Subject
chemotherapy, cryotherapy, ice, oral mucositis, saline mouthwash
Description
Introduction: Oral mucositis is one of the most prevalent and serious complications of chemotherapy that causes
physical discomfort and impacts patients’ functional ability, emotional well-being, and quality of life. It can also delay
treatment, prolong hospitalization, and contribute to psychological issues. This study aimed to compare the effects of
cryotherapy and regular saline mouthwash on oral mucositis in cancer patients resulting from chemotherapy.
Methods: A quasi-experimental study design was used, involving a sample of 64 cancer patients who were recruited
from the Oncology Center at Mansoura University Hospital, Mansoura, Egypt, over 6 months. Two equal groups of
thirty-two cancer patients each were randomly selected into study and control groups from the study population. This
study used a single tool divided into two sections: demographic data, a health-related data sheet, and the World Health
Organization (WHO) mucositis scale. The Monte Carlo exact test was used to obtain an accurate p-value.
Results: Incidence of severe and moderate mucositis was lower in the cryotherapy group on the 21st day, where the p-
value was 0.004. On the 7thand 14th
-day measurements, there were no statistical differences.
Conclusions: The positive effect of cryotherapy on lowering chemotherapy-induced oral mucositis in cancer patients
validated our research hypothesis.
physical discomfort and impacts patients’ functional ability, emotional well-being, and quality of life. It can also delay
treatment, prolong hospitalization, and contribute to psychological issues. This study aimed to compare the effects of
cryotherapy and regular saline mouthwash on oral mucositis in cancer patients resulting from chemotherapy.
Methods: A quasi-experimental study design was used, involving a sample of 64 cancer patients who were recruited
from the Oncology Center at Mansoura University Hospital, Mansoura, Egypt, over 6 months. Two equal groups of
thirty-two cancer patients each were randomly selected into study and control groups from the study population. This
study used a single tool divided into two sections: demographic data, a health-related data sheet, and the World Health
Organization (WHO) mucositis scale. The Monte Carlo exact test was used to obtain an accurate p-value.
Results: Incidence of severe and moderate mucositis was lower in the cryotherapy group on the 21st day, where the p-
value was 0.004. On the 7thand 14th
-day measurements, there were no statistical differences.
Conclusions: The positive effect of cryotherapy on lowering chemotherapy-induced oral mucositis in cancer patients
validated our research hypothesis.
Creator
Heba Abubakr Salama1 , Eslam Mahmoud Abdelfattah2
, Tawfik Ragab Elkhodary3
, and Hanan
Mohamed Mohamed Soliman4
, Tawfik Ragab Elkhodary3
, and Hanan
Mohamed Mohamed Soliman4
Source
http://dx.doi.org/10.20473/jn.v20i4.75655
Date
21 November 2025
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Heba Abubakr Salama1 , Eslam Mahmoud Abdelfattah2
, Tawfik Ragab Elkhodary3
, and Hanan
Mohamed Mohamed Soliman4, “Mitigating chemotherapy-induced oral mucositis: a comparative trial of cryotherapy and normal saline,” Repository Horizon University Indonesia, accessed February 21, 2026, https://repository.horizon.ac.id/items/show/11163.