Glucomannan From Porang (Amorphophallus muelleri) Improves Short-Chain Fatty Acid in Wistar Rat with High-Fat and High-Fructose Diet
Dublin Core
Title
Glucomannan From Porang (Amorphophallus muelleri) Improves Short-Chain Fatty Acid in Wistar Rat with High-Fat and High-Fructose Diet
Subject
glucomannan,
porang, short-chain
fatty acid, wistar rat
porang, short-chain
fatty acid, wistar rat
Description
Introduction: Short-chain fatty acids (SCFAs) improve lipid profile and
prevent coronary artery disease. Searching for nutrition based on local
foods that might raise the body's SCFA levels is imperative. Porang
(Amorphophallus muelleri) is a plant with a high concentration of
glucomannan that is investigated to have a healthy benefit. This study
aimed to investigate the effect of glucomannan from Porang (A.muelleri) on
SCFA in Wistar rats with a high-fat, high-fructose diet.
Methods: This was an experimental study with a randomized and post-test-
only control group design. Thirty male Wistar rats were divided into five
groups: a normal control group, a negative control group given a high-fat,
high-fructose diet, and treatment groups given Porang glucomannan
25mg, 50mg, or 100mg/200gBW. Twenty-eight days after the
intervention, the SCFA level was measured using gas chromatography–
masstry (GC/MS).
Results: The treatment group with Porang glucomannan 50 mg/200gBW
has the highest mean SCFA level (3.98±0.83 nmol/ml) compared to normal
control (1.56±0.24), negative control (2.18±0.45), treatment group
25mg/200gBW (1.81±0.26), and treatment group 100mg/200gBW
(2.58±0.38). Kruskal Wallis test showed significant differences among
groups (p<0.001). Post hoc test revealed that SCFA in the treatment group
50 mg was significantly higher than the normal control and negative
control group.
Conclusion: Glucomannan from Porang (A.muelleri) at 50 mg/200gBW
doses improves short-chain fatty acid in Wistar rats with high-fat and high-
fructose diets.
prevent coronary artery disease. Searching for nutrition based on local
foods that might raise the body's SCFA levels is imperative. Porang
(Amorphophallus muelleri) is a plant with a high concentration of
glucomannan that is investigated to have a healthy benefit. This study
aimed to investigate the effect of glucomannan from Porang (A.muelleri) on
SCFA in Wistar rats with a high-fat, high-fructose diet.
Methods: This was an experimental study with a randomized and post-test-
only control group design. Thirty male Wistar rats were divided into five
groups: a normal control group, a negative control group given a high-fat,
high-fructose diet, and treatment groups given Porang glucomannan
25mg, 50mg, or 100mg/200gBW. Twenty-eight days after the
intervention, the SCFA level was measured using gas chromatography–
masstry (GC/MS).
Results: The treatment group with Porang glucomannan 50 mg/200gBW
has the highest mean SCFA level (3.98±0.83 nmol/ml) compared to normal
control (1.56±0.24), negative control (2.18±0.45), treatment group
25mg/200gBW (1.81±0.26), and treatment group 100mg/200gBW
(2.58±0.38). Kruskal Wallis test showed significant differences among
groups (p<0.001). Post hoc test revealed that SCFA in the treatment group
50 mg was significantly higher than the normal control and negative
control group.
Conclusion: Glucomannan from Porang (A.muelleri) at 50 mg/200gBW
doses improves short-chain fatty acid in Wistar rats with high-fat and high-
fructose diets.
Creator
Agustinus I Wayan Harimawan1*
Source
https://doi.org/10.37363/bnr.2024.52369
Date
21 April 2024
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Agustinus I Wayan Harimawan1*, “Glucomannan From Porang (Amorphophallus muelleri) Improves Short-Chain Fatty Acid in Wistar Rat with High-Fat and High-Fructose Diet,” Repository Horizon University Indonesia, accessed April 26, 2026, https://repository.horizon.ac.id/items/show/11738.