Job Loss and Early-onset Dementia Risk in Middle-aged Adults:
A Longitudinal Study
Dublin Core
Title
Job Loss and Early-onset Dementia Risk in Middle-aged Adults:
A Longitudinal Study
A Longitudinal Study
Subject
cognitive decline
early onset dementia
job loss
middle aged workers
occupational health
early onset dementia
job loss
middle aged workers
occupational health
Description
Early-onset dementia poses a significant public health challenge, particularly due to its
profound impact on working-age individuals (under 65 years). This study investigated the association
between job loss and early-onset dementia in middle-aged adults in Republic of Korea.
Methods: Using National Health Insurance Service data in the Republic of Korea, we analyzed participants aged 45—54 years who were employed by private companies and who underwent health
checkups between 2009 and 2010. Early job loss was defined as involuntary unemployment within two
years of the 2011 index date. The primary outcome was incident dementia, identified using both International Classification of Diseases-10 (ICD-10) codes and antidementia medication use. Adjusted
hazard ratios (HRs) were calculated using Cox proportional hazards models. Subgroup analyses were
conducted by age, household income, residential region, company size, and industrial sector.
Results: Among 1,130,665 participants (mean age 49.2 ± 2.82 years, follow-up of 14.02 years), earlyonset dementia occurred in 3,748 individuals. Of these, 580 cases were from the job loss group
(n = 98,504) and 3,168 cases were from the remaining employed group (n = 1,032,161). Job loss was
significantly associated with an increased risk of early-onset dementia in both males (adjusted HR: 1.75;
95% confidence interval, 1.57—1.95) and females (adjusted HR: 1.51; 95% confidence interval, 1.27—1.78).
Subgroup analyses identified a higher dementia risk among low-income individuals, particularly in
males under 50, females over 50, and those employed in the primary industrial sector.
Conclusion: Job loss was significantly associated with an increased risk of early-onset dementia,
particularly among males, after adjusting for multiple demographic, socioeconomic, and health-related
covariates.
profound impact on working-age individuals (under 65 years). This study investigated the association
between job loss and early-onset dementia in middle-aged adults in Republic of Korea.
Methods: Using National Health Insurance Service data in the Republic of Korea, we analyzed participants aged 45—54 years who were employed by private companies and who underwent health
checkups between 2009 and 2010. Early job loss was defined as involuntary unemployment within two
years of the 2011 index date. The primary outcome was incident dementia, identified using both International Classification of Diseases-10 (ICD-10) codes and antidementia medication use. Adjusted
hazard ratios (HRs) were calculated using Cox proportional hazards models. Subgroup analyses were
conducted by age, household income, residential region, company size, and industrial sector.
Results: Among 1,130,665 participants (mean age 49.2 ± 2.82 years, follow-up of 14.02 years), earlyonset dementia occurred in 3,748 individuals. Of these, 580 cases were from the job loss group
(n = 98,504) and 3,168 cases were from the remaining employed group (n = 1,032,161). Job loss was
significantly associated with an increased risk of early-onset dementia in both males (adjusted HR: 1.75;
95% confidence interval, 1.57—1.95) and females (adjusted HR: 1.51; 95% confidence interval, 1.27—1.78).
Subgroup analyses identified a higher dementia risk among low-income individuals, particularly in
males under 50, females over 50, and those employed in the primary industrial sector.
Conclusion: Job loss was significantly associated with an increased risk of early-onset dementia,
particularly among males, after adjusting for multiple demographic, socioeconomic, and health-related
covariates.
Creator
Heejoo Park 1
, Jian Lee 1
, Youngsun Park 1
, Juho Sim 2
, Byungyoon Yun 2,3,4,*,
Jin-Ha Yoon
, Jian Lee 1
, Youngsun Park 1
, Juho Sim 2
, Byungyoon Yun 2,3,4,*,
Jin-Ha Yoon
Source
https://pdf.sciencedirectassets.com/287282/1-s2.0-S2093791125X00056/1-s2.0-S2093791125000745/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEND%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQDhJDigiWBrCf60TQcgw9LjHdzHDbKrgdi3gWrXtg6x4gIgEbjluG9iLyiTGB3yGWG7PfMhhoxgr4ZTIT2%2B0sak6jAqvAUImf%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAFGgwwNTkwMDM1NDY4NjUiDNgej9PQcbHD1Qz8hyqQBXtHIzJMNNECuh8fjC0exFZq0LOtAbVjzEPFbdACrgXtHgW1fHe3tPnQpexvWiPFMJMugTNIkN5uRItMo6Qw0DsLMFtsAxiVLSDtlDeixUGtdjMPMO05m%2BiEIBZV2n77VUGoWaX5WpK4zx6KqpmV0Z1sf%2BbWxET%2BlhPRCQGgFVOWJUbzFlJOM1XLoZiWr59hYCj86idTv1KNVGu%2BzXBdKfWX9aNEiBiLEExaz8S3lkZgPW4Omyy4YwAErN2jEnI8spnhp3LR7JYtFK16G4%2FPIsUO7OUyyJC1pfI4aSMwLNXxbSBmTZ5SevKhQ2etsQuNrcriY%2F7XUpcPBkUW3wdHuMyV2mkK5YlYx5MqlQX5ZZcfH2BppNjD3mChdeAift3WelzZb78aiJP3c576xScHcCTCOu2ZVo5Gd07BLqW%2B%2B7OHbu0V9H9NQnbeX1aTLwg%2FBESprnRXhKRHw5Yjvc%2BeTPzvuw0NPohIRpAop%2BOWAbeh3g3dtvTcOMFRVShOtt8KMfWvLEMFDZTlsTh2V1GgIGDUsaJBbDR204HBUWCTosujUD9DPpfKvNtvn4JlUYcEfVw3rE%2By4hhs4TcGNBYSdVDfCHsidMdUYwKOusYAMLZXqZvjQ6V%2FO3lZCIeMXXIiHZEr66Yx5PlC%2Be2I9JCPyWHBOF0FS%2FBtyisBD3jJ0Ys%2B8ArT70wgwxR81N%2F8gpgDTxxcNdiBmbBDPdy8nH8Sk1B2kfiv7SHqwmv3t1FjK3gEWLXxOBkZG22%2BCCNlSbOW27V4olc%2BrvRVYrpUupQoCs1sWWpS5%2BBWfhKaXRzsja8Kmz9jlYSjOAAkd3cOxUHU4hB79dD6ps45wRzz8Z%2BWLuKXt7340CoRhskISS5UP4MsMKugms0GOrEBZBi0KWuIrFSa%2Bmq1L3sh1%2FBZszJmuU4hJfyxr%2BIlOr452GoUWCVuHRlRCAWFz3hJUe8sIPGqYhxT%2FtgT4kOC6XI%2F7IM%2FOIZBXRocYZW9C33Dii%2BsIc692cKCUN2wetoMylQ%2FDbshc%2FJjUGmoPrJuw2d%2BZ6CE%2Bgn7mWON77jzyFvjFTU%2FN6P%2BdUVYrCWk0rUxrVUN4nt29lP6RsU%2FfPyr%2BCj4%2FzzvWdJxTWHxWtaL8r8W&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20260303T081631Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY2VI7MHNP%2F20260303%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=43b8c3344d93f34524c90028e213dcd32068176cf2fc73e30e57094933e21a7d&hash=ca3405ed1c775a44d9565deed34269a50352eb029992c3bca9d9a9b5db22ee5d&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2093791125000745&tid=spdf-47e9f7fb-b1a5-42a7-b028-616e7eb523b7&sid=2ded17629244b949e60afc0450ecf4110ca9gxrqa&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&rh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0b015e065155525451&rr=9d673311693a6d12&cc=id
Publisher
Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea 2Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea 3 The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Republic of Korea 4 Institute for Innovation in Digital Healthcare, Yonsei University Health System, Seoul, Republic of Korea
Date
12 September 2025
Contributor
Fajar Bagus Wijanarko
Format
pdf
Language
english
Type
text
Files
Citation
Heejoo Park 1
, Jian Lee 1
, Youngsun Park 1
, Juho Sim 2
, Byungyoon Yun 2,3,4,*,
Jin-Ha Yoon, “Job Loss and Early-onset Dementia Risk in Middle-aged Adults:
A Longitudinal Study,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12034.
A Longitudinal Study,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12034.