Aspirin increases the risk of acute kidney injury in critical patients with chest trauma: a retrospective cohort study
Dublin Core
Title
Aspirin increases the risk of acute kidney injury in critical patients with chest trauma: a retrospective cohort study
Subject
NSAIDs, Chest trauma, AKI, Aspirin, Ibuprofen, Ketorolac
Description
Abstract
Purpose Non-steroidal anti-inflammatory drugs (NSAIDs) are increasingly utilized in trauma patients, particularly
those with critical chest trauma who are susceptible to significant blood loss, leading to renal hypoperfusion. Acute
kidney injury (AKI) is known to carry a poor prognosis in chest trauma patients. Therefore, investigating the potential
association between NSAID use and AKI risk in critical patients with chest trauma is crucial.
Methods We selected patients admitted to the intensive care unit (ICU) with chest trauma from the Medical
Information Mart for Intensive Care III (MIMIC-III) dataset (2001–2012) and the Medical Information Mart for Intensive
Care IV (MIMIC-IV) dataset (2013–2019). Propensity score matching (PSM) was used to match patients receiving
NSAIDs with those not receiving treatment. Logistic regression was employed to assess the association between
different types of NSAIDs and AKI in these patients.
Results In MIMIC-IV, NSAID use significantly increased the risk of AKI in critical patients with chest trauma (OR 1.99;
95% CI 1.04 to 3.85). Subgroup analysis revealed that aspirin significantly increased AKI risk in both MIMIC-III (OR
1.81; 95% CI 1.02 to 3.2) and MIMIC-IV (OR 2.47; 95% CI 1.26 to 4.85). However, ibuprofen and ketorolac use were not
associated with AKI in these patients.
Conclusion We observed a significant association between aspirin use and an elevated risk of AKI in critical patients
with chest trauma. These findings suggest that pain management strategies involving ibuprofen and ketorolac may
be more appropriate for this patient population.
Keywords NSAIDs, Chest trauma, AKI, Aspirin, Ibuprofen, Ketorolac
Purpose Non-steroidal anti-inflammatory drugs (NSAIDs) are increasingly utilized in trauma patients, particularly
those with critical chest trauma who are susceptible to significant blood loss, leading to renal hypoperfusion. Acute
kidney injury (AKI) is known to carry a poor prognosis in chest trauma patients. Therefore, investigating the potential
association between NSAID use and AKI risk in critical patients with chest trauma is crucial.
Methods We selected patients admitted to the intensive care unit (ICU) with chest trauma from the Medical
Information Mart for Intensive Care III (MIMIC-III) dataset (2001–2012) and the Medical Information Mart for Intensive
Care IV (MIMIC-IV) dataset (2013–2019). Propensity score matching (PSM) was used to match patients receiving
NSAIDs with those not receiving treatment. Logistic regression was employed to assess the association between
different types of NSAIDs and AKI in these patients.
Results In MIMIC-IV, NSAID use significantly increased the risk of AKI in critical patients with chest trauma (OR 1.99;
95% CI 1.04 to 3.85). Subgroup analysis revealed that aspirin significantly increased AKI risk in both MIMIC-III (OR
1.81; 95% CI 1.02 to 3.2) and MIMIC-IV (OR 2.47; 95% CI 1.26 to 4.85). However, ibuprofen and ketorolac use were not
associated with AKI in these patients.
Conclusion We observed a significant association between aspirin use and an elevated risk of AKI in critical patients
with chest trauma. These findings suggest that pain management strategies involving ibuprofen and ketorolac may
be more appropriate for this patient population.
Keywords NSAIDs, Chest trauma, AKI, Aspirin, Ibuprofen, Ketorolac
Creator
Yu Huang1† , Hongchun Xu1†, Feng Xiang1†, Wei Feng1
, Yuchao Ma1* and Longyu Jin1*
, Yuchao Ma1* and Longyu Jin1*
Source
https://doi.org/10.1186/s12245-025-00835-1
Date
2025
Contributor
Peri Irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Yu Huang1† , Hongchun Xu1†, Feng Xiang1†, Wei Feng1
, Yuchao Ma1* and Longyu Jin1*, “Aspirin increases the risk of acute kidney injury in critical patients with chest trauma: a retrospective cohort study,” Repository Horizon University Indonesia, accessed April 11, 2026, https://repository.horizon.ac.id/items/show/12669.