PROSIDING INTERNASIONAL KEPERAWATAN Proceedings of the International Conference on Nursing and Health Sciences, Volume 4 No 1
CHOLECALCIFEROL PREVENT OBESITY IN RATS UNDER HIGH FAT HIGH FRUCTOSE DIET
Dublin Core
Title
PROSIDING INTERNASIONAL KEPERAWATAN Proceedings of the International Conference on Nursing and Health Sciences, Volume 4 No 1
CHOLECALCIFEROL PREVENT OBESITY IN RATS UNDER HIGH FAT HIGH FRUCTOSE DIET
CHOLECALCIFEROL PREVENT OBESITY IN RATS UNDER HIGH FAT HIGH FRUCTOSE DIET
Subject
cholecalciferol; lipid profile; obesity
Description
Obesity is an accumulation of fat body condition due to calories and energy imbalance. Obesity often
coexists with low vitamin D status. Low vitamin D status is known to establish abnormality in lipid profile
and increasing weight. This study aims to look at the effect of the dose and duration of Cholecalciferol
supplementation on lipid profiles in male rats induced by high fat high fructose diet. In this study, we
conducted an experiment using a randomized pre and posttest control group design. This study analyzed 3
groups of male Sprague Dawley strain rats that were induced with a high fat high fructose diet to become
diet-induced obesity rats. Each group either receives cholecalciferol in the amount of 2.500 IU/200gr/day
in P1 group, 5.000IU/200gr/day in P2 group, and 10.000 IU/200gr/day in P3 group for 8 weeks. Lipid profile
outcomes analyzed include levels of total cholesterol, triglycerides, High-density lipoprotein (HDL), and
low-density lipoprotein (LDL). Cholecalciferol supplementation resulted in significant differences between
all lipid parameters. Total cholesterol levels are lowest in the P3 group with a mean of 102.09±2.45.
followed by P2 (115.80±3.98) and P1 group (138.33±4.82), and highest in the control group (196.52±4.36).
Triglyceride levels are also lowest in the P3 group with a mean of 76.03±3.81, followed by the P2
(115.80±3.98) and P1 (138.33±4.82) groups, with the highest in the control group (134.46±5.84). HDL
levels are instead highest in the P3 group with a mean of 80.93±8.29, followed by P2 (77.98±10.38) and P1
(66.54±7.25) group, while lowest in the control group (25.45±2.32). LDL levels are lowest on the P3 group
with a mean of 33.71±2.49, followed by P2 (38.72±1.41), and P1 (47.62±2.76) group, while highest in the
control group with a mean of 82.96±1.88. Cholecalciferol supplementation was found to provide a beneficial
effect across all lipid profile outcomes in this study such as total cholesterol, triglyceride, HDL, and LDL
in high fat high fructose induced male Sprague Dawley rats.
coexists with low vitamin D status. Low vitamin D status is known to establish abnormality in lipid profile
and increasing weight. This study aims to look at the effect of the dose and duration of Cholecalciferol
supplementation on lipid profiles in male rats induced by high fat high fructose diet. In this study, we
conducted an experiment using a randomized pre and posttest control group design. This study analyzed 3
groups of male Sprague Dawley strain rats that were induced with a high fat high fructose diet to become
diet-induced obesity rats. Each group either receives cholecalciferol in the amount of 2.500 IU/200gr/day
in P1 group, 5.000IU/200gr/day in P2 group, and 10.000 IU/200gr/day in P3 group for 8 weeks. Lipid profile
outcomes analyzed include levels of total cholesterol, triglycerides, High-density lipoprotein (HDL), and
low-density lipoprotein (LDL). Cholecalciferol supplementation resulted in significant differences between
all lipid parameters. Total cholesterol levels are lowest in the P3 group with a mean of 102.09±2.45.
followed by P2 (115.80±3.98) and P1 group (138.33±4.82), and highest in the control group (196.52±4.36).
Triglyceride levels are also lowest in the P3 group with a mean of 76.03±3.81, followed by the P2
(115.80±3.98) and P1 (138.33±4.82) groups, with the highest in the control group (134.46±5.84). HDL
levels are instead highest in the P3 group with a mean of 80.93±8.29, followed by P2 (77.98±10.38) and P1
(66.54±7.25) group, while lowest in the control group (25.45±2.32). LDL levels are lowest on the P3 group
with a mean of 33.71±2.49, followed by P2 (38.72±1.41), and P1 (47.62±2.76) group, while highest in the
control group with a mean of 82.96±1.88. Cholecalciferol supplementation was found to provide a beneficial
effect across all lipid profile outcomes in this study such as total cholesterol, triglyceride, HDL, and LDL
in high fat high fructose induced male Sprague Dawley rats.
Creator
Dea Anenta, Budiyanti Wiboworini, Muthmainah
Source
http://jurnal.globalhealthsciencegroup.com/index.php/PICNHS
Date
January - June 2023
Contributor
PERI IRAWAN
Format
PDF
Language
ENGLISH
Type
TEXT
Files
Citation
Dea Anenta, Budiyanti Wiboworini, Muthmainah, “PROSIDING INTERNASIONAL KEPERAWATAN Proceedings of the International Conference on Nursing and Health Sciences, Volume 4 No 1
CHOLECALCIFEROL PREVENT OBESITY IN RATS UNDER HIGH FAT HIGH FRUCTOSE DIET,” Repository Horizon University Indonesia, accessed February 3, 2025, https://repository.horizon.ac.id/items/show/2800.
CHOLECALCIFEROL PREVENT OBESITY IN RATS UNDER HIGH FAT HIGH FRUCTOSE DIET,” Repository Horizon University Indonesia, accessed February 3, 2025, https://repository.horizon.ac.id/items/show/2800.