Quick and effective improvement of leucine enriched dietary supplement on malnutrition in acute stroke patients receiving enteral tube feeding
Dublin Core
Title
Quick and effective improvement of leucine enriched dietary supplement on malnutrition in acute stroke patients receiving enteral tube feeding
Subject
Severe stroke, Enteral tube feeding, Malnutrition, Transthyretin, Leucine, BCAA
Description
Background: Malnutrition often occurs in acute stroke patients receiving enteral tube feeding (ETF). Unless
malnutrition is improved, their clinical outcome is poor. However, strategies to improve malnutrition in these
patients have not been established. Branched-chain amino acids (BCAA) may enhance protein synthesis and
attenuate inflammation. Our study aimed to investigate whether a leucine enriched BCAA dietary supplement
(LEBDs) could quickly increase serum levels of albumin (Alb) or transthyretin (TTR) and decrease high-sensitivity Creactive protein (CRP) in the development of severe malnutrition within a few days after stroke onset compared to
standard BCAA dietary supplement (SBDs).
Methods: We retrospectively included acute stroke patients who: 1) were admitted between August 2016 and July
2017; 2) underwent ETF for 7 days or longer after admission, and 3) underwent blood examination of Alb, TTR, and
CRP on admission, the fifth day and the seventh day. We defined severe malnutrition as severe hypoproteinemia:
decrease of TTR to less than 15 mg/dl on the 5th day. In LEBDs and SBDs groups, patients started to receive a
dietary supplement containing leucine of 1.44 and 0. 72 g twice a day on the fifth day, respectively. We evaluated
Alb (g/dl), TTR (mg/dl), and CRP (mg/dl) on admission, the fifth day, and the seventh day.
Results: Twenty-nine patients met our inclusion criteria:15 in LEBDs and 14 in SBDs. In LEBDs and SBDs groups, the
median Alb was 3.5 and 3.3 g/dl, TTR was 12.7 and 10.7 mg/dl, and CRP was 1.02 and 0.673 mg/dl on admission,
respectively. In LEBDs, the median Alb and TTR decreased to 2.6 g/dl and 11.9 mg/dl, and CRP increased to 5.337
mg/dl on the fifth day. On the 7th day, TTR increased, and CRP decreased, although Alb did not improve. In SBDs,
the median Alb and TTR decreased to 2.6 g/dl and 9.7 mg/dl, and CRP increased to 4.077 mg/dl on the fifth day. On
the 7th day, Alb, TTR, and CRP did not improve.
Conclusion: In acute stroke patients receiving leucine enriched BCAA dietary supplement, quick improvements in
transthyretin and CRP were observed.
malnutrition is improved, their clinical outcome is poor. However, strategies to improve malnutrition in these
patients have not been established. Branched-chain amino acids (BCAA) may enhance protein synthesis and
attenuate inflammation. Our study aimed to investigate whether a leucine enriched BCAA dietary supplement
(LEBDs) could quickly increase serum levels of albumin (Alb) or transthyretin (TTR) and decrease high-sensitivity Creactive protein (CRP) in the development of severe malnutrition within a few days after stroke onset compared to
standard BCAA dietary supplement (SBDs).
Methods: We retrospectively included acute stroke patients who: 1) were admitted between August 2016 and July
2017; 2) underwent ETF for 7 days or longer after admission, and 3) underwent blood examination of Alb, TTR, and
CRP on admission, the fifth day and the seventh day. We defined severe malnutrition as severe hypoproteinemia:
decrease of TTR to less than 15 mg/dl on the 5th day. In LEBDs and SBDs groups, patients started to receive a
dietary supplement containing leucine of 1.44 and 0. 72 g twice a day on the fifth day, respectively. We evaluated
Alb (g/dl), TTR (mg/dl), and CRP (mg/dl) on admission, the fifth day, and the seventh day.
Results: Twenty-nine patients met our inclusion criteria:15 in LEBDs and 14 in SBDs. In LEBDs and SBDs groups, the
median Alb was 3.5 and 3.3 g/dl, TTR was 12.7 and 10.7 mg/dl, and CRP was 1.02 and 0.673 mg/dl on admission,
respectively. In LEBDs, the median Alb and TTR decreased to 2.6 g/dl and 11.9 mg/dl, and CRP increased to 5.337
mg/dl on the fifth day. On the 7th day, TTR increased, and CRP decreased, although Alb did not improve. In SBDs,
the median Alb and TTR decreased to 2.6 g/dl and 9.7 mg/dl, and CRP increased to 4.077 mg/dl on the fifth day. On
the 7th day, Alb, TTR, and CRP did not improve.
Conclusion: In acute stroke patients receiving leucine enriched BCAA dietary supplement, quick improvements in
transthyretin and CRP were observed.
Creator
Takahisa Mori and Kazuhiro Yoshioka
Publisher
BMC Emergency Medicine
Date
(2020) 20:56
Contributor
Fajar bagus W
Format
PDF
Language
Indonesia
Type
Text
Files
Collection
Citation
Takahisa Mori and Kazuhiro Yoshioka, “Quick and effective improvement of leucine enriched dietary supplement on malnutrition in acute stroke patients receiving enteral tube feeding,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/3579.