Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19
Dublin Core
Title
Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19
Subject
COVID-19, Hemogram, Hemogram-derived ratio, Neutrophil-to-platelet ratio, Neutrophil-to-lymphocyte
ratio, ICU admission
ratio, ICU admission
Description
Background: The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a
torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological
mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse
clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the
objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte
ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio
(NPR), could help identify patients who at risk of admission at Intensive Care Units.
Methods: A retrospective observational study was performed at HM Hospitales including electronic health records
from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two
groups, admitted at ICU or not.
Results: Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at
the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found
significant differences in NLR (6.9 [4–11.7] vs 4.1 [2.6–7.6], p < 0.0001), PLR (2 [1.4–3.3] vs 1.9 [1.3–2.9], p = 0.023),
NPR (3 [2.1–4.2] vs 2.3 [1.6–3.2], p < 0.0001) and SII (13 [6.5–25.7] vs 9 [4.9–17.5], p < 0.0001) compared to those
who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived
ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98–1.22, p = 0.055).
Conclusions: Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the
novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19.
torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological
mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse
clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the
objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte
ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio
(NPR), could help identify patients who at risk of admission at Intensive Care Units.
Methods: A retrospective observational study was performed at HM Hospitales including electronic health records
from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two
groups, admitted at ICU or not.
Results: Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at
the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found
significant differences in NLR (6.9 [4–11.7] vs 4.1 [2.6–7.6], p < 0.0001), PLR (2 [1.4–3.3] vs 1.9 [1.3–2.9], p = 0.023),
NPR (3 [2.1–4.2] vs 2.3 [1.6–3.2], p < 0.0001) and SII (13 [6.5–25.7] vs 9 [4.9–17.5], p < 0.0001) compared to those
who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived
ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98–1.22, p = 0.055).
Conclusions: Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the
novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19.
Creator
Sara Velazquez, Rodrigo Madurga, José María Castellano, Jesús Rodriguez-Pascual, Santiago Ruiz de Aguiar Diaz Obregon, Sara Jimeno, Juan Ignacio Montero, Paula Sol Ventura Wichner and Alejandro López-Escobar
Publisher
BMC Emergency Medicine
Date
(2021) 21:89
Contributor
Fajar bagus W
Format
PDF
Language
Indonesia
Type
Text
Files
Collection
Citation
Sara Velazquez, Rodrigo Madurga, José María Castellano, Jesús Rodriguez-Pascual, Santiago Ruiz de Aguiar Diaz Obregon, Sara Jimeno, Juan Ignacio Montero, Paula Sol Ventura Wichner and Alejandro López-Escobar, “Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19,” Repository Horizon University Indonesia, accessed April 3, 2025, https://repository.horizon.ac.id/items/show/3793.