Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis
Dublin Core
Title
Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis
Subject
Sepsis, C-reactive protein, Procalcitonin, Immunocyte, Diagnosis
Description
Background: Evidence suggests that C-reactive protein (CRP), procalcitonin (PCT), and immune cells can predict sepsis
severity in adult patients. However, the specific values of these indicators are not consistent in predicting prognosis.
Methods: A retrospective study analyzed the medical records of 194 patients based on the concept of sepsis in 2016
(Sepsis 3.0) from January 2017 to December 2019. A comparative analysis of inflammatory factors associated with
patients in the sepsis survival and the non-survival group was performed. The concentrations of CRP and PCT,
neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were
measured. ROC curve was used to assess the diagnosis and analysis of the selected indices of sepsis. According to each
index’s cut-off value of the ROC curve, the patients were divided into two groups, and the prognosis was calculated.
Results: Among the 194 patients, 32 died (16.49%), the median age of the patients was 79 (66.0, 83.3) years, and 118
were male (60.8%). Analysis of related inflammatory indicators showed that CRP, NLR, MLR, PLR, and CRP*PCT in the
non-survival group were statistically higher than those in the survival group (all p values were < 0.05). Regression
analysis showed that PCT, CRP, NLR, PLR, and CRP*PCT were all independent prognostic factors for patients. The ROC
curve results showed that CRP*PCT had the best diagnostic value (AUC = 0.915). The cut-off values of PCT, CRP, NLR,
PLR, MLR, and CRP*PCT were 0.25 ng/mL, 85.00 mg/L, 8.66, 275.51, 0.74%, and 5.85 (mg/L)2
, respectively. Kaplan-Meier
survival estimate showed that patient prognosis between the CRP, PCT, NLR, PLR, and CRP*PCT was statistically
different (all values P < 0.05, respectively). However, there was no statistically significant difference in gender and MLR
(all values P > 0.05, respectively), grouping based on diagnostic cut-off values.
Conclusions: In this study, inflammation-related markers PCT, CRP, NLR, MLR, PLR, and CRP*PCT can be used as
independent risk factors affecting the prognosis of patients with sepsis. Furthermore, except for MRL, these indicators
have cut-off values for predicting patient death.
severity in adult patients. However, the specific values of these indicators are not consistent in predicting prognosis.
Methods: A retrospective study analyzed the medical records of 194 patients based on the concept of sepsis in 2016
(Sepsis 3.0) from January 2017 to December 2019. A comparative analysis of inflammatory factors associated with
patients in the sepsis survival and the non-survival group was performed. The concentrations of CRP and PCT,
neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were
measured. ROC curve was used to assess the diagnosis and analysis of the selected indices of sepsis. According to each
index’s cut-off value of the ROC curve, the patients were divided into two groups, and the prognosis was calculated.
Results: Among the 194 patients, 32 died (16.49%), the median age of the patients was 79 (66.0, 83.3) years, and 118
were male (60.8%). Analysis of related inflammatory indicators showed that CRP, NLR, MLR, PLR, and CRP*PCT in the
non-survival group were statistically higher than those in the survival group (all p values were < 0.05). Regression
analysis showed that PCT, CRP, NLR, PLR, and CRP*PCT were all independent prognostic factors for patients. The ROC
curve results showed that CRP*PCT had the best diagnostic value (AUC = 0.915). The cut-off values of PCT, CRP, NLR,
PLR, MLR, and CRP*PCT were 0.25 ng/mL, 85.00 mg/L, 8.66, 275.51, 0.74%, and 5.85 (mg/L)2
, respectively. Kaplan-Meier
survival estimate showed that patient prognosis between the CRP, PCT, NLR, PLR, and CRP*PCT was statistically
different (all values P < 0.05, respectively). However, there was no statistically significant difference in gender and MLR
(all values P > 0.05, respectively), grouping based on diagnostic cut-off values.
Conclusions: In this study, inflammation-related markers PCT, CRP, NLR, MLR, PLR, and CRP*PCT can be used as
independent risk factors affecting the prognosis of patients with sepsis. Furthermore, except for MRL, these indicators
have cut-off values for predicting patient death.
Creator
Tian Tian, Bing Wei and Junyu Wang
Publisher
BMC Emergency Medicine
Date
(2021) 21:81
Contributor
Fajar Bagus W
Format
PDF
Language
Indonesia
Type
Text
Files
Collection
Citation
Tian Tian, Bing Wei and Junyu Wang, “Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis,” Repository Horizon University Indonesia, accessed November 10, 2024, https://repository.horizon.ac.id/items/show/3867.