Pain management of nalbuphine and sufentanil in patients admitted intensive care unit of diferent ages
Dublin Core
Title
Pain management of nalbuphine and sufentanil in patients admitted intensive care unit of diferent ages
Subject
Nalbuphine, Sufentanil, Analgesia, Sedation, Intensive care unit
Description
Background: Pain relief for patients in the intensive care unit (ICU) can improve treatment outcomes and reduce the
burden on doctors and nurses. This study aims to report the clinical analgesic and sedative efects of nalbuphine and
sufentanil on ICU patients.
Methods: This study retrospectively analyzed the medical records of 87 critically ill patients who received nalbuphine
or sufentanil infusion in the ICU, including demographic data, diagnosis, Acute Physiology and Chronic Health Evaluation (APACHE) II, Critical Care Pain Observation Tool (CPOT), Richmond Agitation-Sedation Scale (RASS), systolic and
diastolic blood pressure, heart rate and blood oxygen saturation (SpO2). The primary outcomes of this study were
CPOT and RASS scores. The secondary outcomes were hemodynamic changes, including systolic blood pressure, diastolic blood pressure, heart rate, and SpO2. The adverse events recorded during pain management, such as hypoxemia,
respiration depression and bradycardia, were also collected and analyzed.
Results: None of the patients in both groups experienced episode of hypoxemia, respiration depression and
bradycardia. However, age-stratifed analyses showed that nalbuphine has a better analgesic efect than sufentanil
for patients aged≤60 (P<0.05). In contrast, sufentanil showed a better analgesic efect than nalbuphine for patients
aged>60 ( P<0.05). Furthermore, nalbuphine has a signifcantly better sedative efect than sufentanil for patients
aged≤60 (P<0.05).
Conclusion: ICU patients of diferent age groups may be suitable for diferent analgesics. For patients under the age
of 60, nalbuphine has better analgesia and sedation than sufentanil, and does not cause respiratory depression and
drastic hemodynamic changes.
burden on doctors and nurses. This study aims to report the clinical analgesic and sedative efects of nalbuphine and
sufentanil on ICU patients.
Methods: This study retrospectively analyzed the medical records of 87 critically ill patients who received nalbuphine
or sufentanil infusion in the ICU, including demographic data, diagnosis, Acute Physiology and Chronic Health Evaluation (APACHE) II, Critical Care Pain Observation Tool (CPOT), Richmond Agitation-Sedation Scale (RASS), systolic and
diastolic blood pressure, heart rate and blood oxygen saturation (SpO2). The primary outcomes of this study were
CPOT and RASS scores. The secondary outcomes were hemodynamic changes, including systolic blood pressure, diastolic blood pressure, heart rate, and SpO2. The adverse events recorded during pain management, such as hypoxemia,
respiration depression and bradycardia, were also collected and analyzed.
Results: None of the patients in both groups experienced episode of hypoxemia, respiration depression and
bradycardia. However, age-stratifed analyses showed that nalbuphine has a better analgesic efect than sufentanil
for patients aged≤60 (P<0.05). In contrast, sufentanil showed a better analgesic efect than nalbuphine for patients
aged>60 ( P<0.05). Furthermore, nalbuphine has a signifcantly better sedative efect than sufentanil for patients
aged≤60 (P<0.05).
Conclusion: ICU patients of diferent age groups may be suitable for diferent analgesics. For patients under the age
of 60, nalbuphine has better analgesia and sedation than sufentanil, and does not cause respiratory depression and
drastic hemodynamic changes.
Creator
Kaiqiang Ji, Xiaoying Gong, Ting Luan, Xiaopeng Gao and Bin Zang
Publisher
BMC Emergency Medicine
Date
(2022) 22:50
Contributor
Fajar bagus W
Format
PDF
Language
English
Type
Text
Files
Collection
Citation
Kaiqiang Ji, Xiaoying Gong, Ting Luan, Xiaopeng Gao and Bin Zang, “Pain management of nalbuphine and sufentanil in patients admitted intensive care unit of diferent ages,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/3955.