Prescribing errors in post - COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post - COVID-19 outpatient clinic
Dublin Core
Title
Prescribing errors in post - COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post - COVID-19 outpatient clinic
Subject
COVID-19, Prescribing errors, Pharmacotherapeutic stewardship, Clinical pharmacology
Description
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019
(COVID-19), has challenged healthcare globally. An acute increase in the number of hospitalized patients has neces‑
sitated a rigorous reorganization of hospital care, thereby creating circumstances that previously have been identifed
as facilitating prescribing errors (PEs), e.g. a demanding work environment, a high turnover of doctors, and prescrib‑
ing beyond expertise. Hospitalized COVID-19 patients may be at risk of PEs, potentially resulting in patient harm. We
determined the prevalence, severity, and risk factors for PEs in post–COVID-19 patients, hospitalized during the frst
wave of COVID-19 in the Netherlands, 3months after discharge.
Methods: This prospective observational cohort study recruited patients who visited a post-COVID-19 outpatient
clinic of an academic hospital in the Netherlands, 3months after COVID-19 hospitalization, between June 1 and
October 1 2020. All patients with appointments were eligible for inclusion. The prevalence and severity of PEs were
assessed in a multidisciplinary consensus meeting. Odds ratios (ORs) were calculated by univariate and multivariate
analysis to identify independent risk factors for PEs.
Results: Ninety-eight patients were included, of whom 92% had ≥1 PE and 8% experienced medication-related
harm requiring an immediate change in medication therapy to prevent detoriation. Overall, 68% of all identifed PEs
were made during or after the COVID-19 related hospitalization. Multivariate analyses identifed ICU admission (OR
6.08, 95% CI 2.16–17.09) and a medical history of COPD / asthma (OR 5.36, 95% CI 1.34–21.5) as independent risk fac‑
tors for PEs.
Conclusions: PEs occurred frequently during the SARS-CoV-2 pandemic. Patients admitted to an ICU during COVID19 hospitalization or who had a medical history of COPD / asthma were at risk of PEs. These risk factors can be used
(COVID-19), has challenged healthcare globally. An acute increase in the number of hospitalized patients has neces‑
sitated a rigorous reorganization of hospital care, thereby creating circumstances that previously have been identifed
as facilitating prescribing errors (PEs), e.g. a demanding work environment, a high turnover of doctors, and prescrib‑
ing beyond expertise. Hospitalized COVID-19 patients may be at risk of PEs, potentially resulting in patient harm. We
determined the prevalence, severity, and risk factors for PEs in post–COVID-19 patients, hospitalized during the frst
wave of COVID-19 in the Netherlands, 3months after discharge.
Methods: This prospective observational cohort study recruited patients who visited a post-COVID-19 outpatient
clinic of an academic hospital in the Netherlands, 3months after COVID-19 hospitalization, between June 1 and
October 1 2020. All patients with appointments were eligible for inclusion. The prevalence and severity of PEs were
assessed in a multidisciplinary consensus meeting. Odds ratios (ORs) were calculated by univariate and multivariate
analysis to identify independent risk factors for PEs.
Results: Ninety-eight patients were included, of whom 92% had ≥1 PE and 8% experienced medication-related
harm requiring an immediate change in medication therapy to prevent detoriation. Overall, 68% of all identifed PEs
were made during or after the COVID-19 related hospitalization. Multivariate analyses identifed ICU admission (OR
6.08, 95% CI 2.16–17.09) and a medical history of COPD / asthma (OR 5.36, 95% CI 1.34–21.5) as independent risk fac‑
tors for PEs.
Conclusions: PEs occurred frequently during the SARS-CoV-2 pandemic. Patients admitted to an ICU during COVID19 hospitalization or who had a medical history of COPD / asthma were at risk of PEs. These risk factors can be used
Creator
Rashudy F. Mahomedradja, Tessa O. van den Beukel, Maaike van den Bos, Steven Wang, Kirsten A. Kalverda, Birgit I. Lissenberg‑Witte, Marianne A. Kuijvenhoven, Esther J. Nossent, Majon Muller, Kim C. E. Sigalof, Jelle Tichelaar and Michiel A. van Agtmael
Publisher
BMC Emergency Medicine
Date
(2022) 22:35
Contributor
Fajar Bagus W
Format
PDF
Language
English
Type
Text
Files
Collection
Citation
Rashudy F. Mahomedradja, Tessa O. van den Beukel, Maaike van den Bos, Steven Wang, Kirsten A. Kalverda, Birgit I. Lissenberg‑Witte, Marianne A. Kuijvenhoven, Esther J. Nossent, Majon Muller, Kim C. E. Sigalof, Jelle Tichelaar and Michiel A. van Agtmael , “Prescribing errors in post - COVID-19 patients: prevalence, severity, and risk factors in patients visiting a post - COVID-19 outpatient clinic,” Repository Horizon University Indonesia, accessed November 21, 2024, https://repository.horizon.ac.id/items/show/4051.