Study of the value of homocysteine levels in predicting cognitive dysfunction in patients after acute carbon monoxide poisoning
Dublin Core
Title
Study of the value of homocysteine levels in predicting cognitive dysfunction in patients after acute carbon monoxide poisoning
Subject
Carbon monoxide poisoning, Cognitive dysfunction, Homocysteine, Hyperhomocysteinemia
Description
Purpose: The purpose of this research was to assess the value of homocysteine (HCY) levels in predicting cognitive
dysfunction in patients after acute carbon monoxide (CO) poisoning.
Methods: A total of 115 patients who were admitted to the emergency department of Yinzhou NO. 2 Hospital after
CO poisoning between January 2017 and December 2021 were enrolled in this retrospective study. All patients were
followed up for 1 month. According to the Mini–Mental State Examination (MMSE) scores, patients were divided into
two groups. The demographic and clinical characteristics and magnetic resonance imaging (MRI) results were gathered and statistically analysed.
Results: Twenty-six and 89 patients were ultimately enrolled in the cognitive dysfunction and control groups,
respectively. There were signifcant diferences between the groups in terms of age, coma duration, and carboxyhaemoglobin (COHB), lactate and HCY levels (p <0.05), but there were no signifcant diferences in white blood cell
(WBC) counts or aspartate transaminase (AST), alanine transaminase (ALT), creatinine, troponin T, creatinine kinase
(CK), or creatinine kinase muscle and brain (CK-MB) levels (p >0.05). Univariate and multivariate analyses identifed
that a higher HCY level (OR 2.979, 95% CI 1.851-5.596, p <0.001) was an independent risk factor for patient cognitive
dysfunction after acute CO poisoning. Linear regression analysis showed a negative correlation between MMSE scores
and HCY levels (r =−0.880, P <0.001). According to the MRI results, the most common lesion site was the globus
pallidus, and the central ovale, difuse white matter, corona radiata, basal ganglia (other than the globus pallidus) and
cerebral cortex were also involved.
Conclusions: Higher HCY levels were associated with cognitive impairment and were independent risk factors for
cognitive impairment after acute CO poisoning. The level of HCY was negatively correlated with the degree of cognitive impairment.
dysfunction in patients after acute carbon monoxide (CO) poisoning.
Methods: A total of 115 patients who were admitted to the emergency department of Yinzhou NO. 2 Hospital after
CO poisoning between January 2017 and December 2021 were enrolled in this retrospective study. All patients were
followed up for 1 month. According to the Mini–Mental State Examination (MMSE) scores, patients were divided into
two groups. The demographic and clinical characteristics and magnetic resonance imaging (MRI) results were gathered and statistically analysed.
Results: Twenty-six and 89 patients were ultimately enrolled in the cognitive dysfunction and control groups,
respectively. There were signifcant diferences between the groups in terms of age, coma duration, and carboxyhaemoglobin (COHB), lactate and HCY levels (p <0.05), but there were no signifcant diferences in white blood cell
(WBC) counts or aspartate transaminase (AST), alanine transaminase (ALT), creatinine, troponin T, creatinine kinase
(CK), or creatinine kinase muscle and brain (CK-MB) levels (p >0.05). Univariate and multivariate analyses identifed
that a higher HCY level (OR 2.979, 95% CI 1.851-5.596, p <0.001) was an independent risk factor for patient cognitive
dysfunction after acute CO poisoning. Linear regression analysis showed a negative correlation between MMSE scores
and HCY levels (r =−0.880, P <0.001). According to the MRI results, the most common lesion site was the globus
pallidus, and the central ovale, difuse white matter, corona radiata, basal ganglia (other than the globus pallidus) and
cerebral cortex were also involved.
Conclusions: Higher HCY levels were associated with cognitive impairment and were independent risk factors for
cognitive impairment after acute CO poisoning. The level of HCY was negatively correlated with the degree of cognitive impairment.
Creator
Wei Ren and Xiao Shuai Zhou
Publisher
BMC Emergency Medicine
Date
(2022) 22:133
Contributor
Fajar bagus W
Format
PDF
Language
English
Type
Text
Files
Collection
Citation
Wei Ren and Xiao Shuai Zhou, “Study of the value of homocysteine levels in predicting cognitive dysfunction in patients after acute carbon monoxide poisoning,” Repository Horizon University Indonesia, accessed September 20, 2024, https://repository.horizon.ac.id/items/show/4238.