Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Tyrosine Kinase Inhibitor Resistance in Pediatric Chronic Myeloid Leukemia: A Case Report
Dublin Core
Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Tyrosine Kinase Inhibitor Resistance in Pediatric Chronic Myeloid Leukemia: A Case Report
Tyrosine Kinase Inhibitor Resistance in Pediatric Chronic Myeloid Leukemia: A Case Report
Subject
children, chronic myeloid leukemia, tyrosine kinase inhibitor
Description
Pediatric chronic myeloid leukemia (CML) is a hematopoietic malignancy, treated by tyrosine kinase inhibitor (TKI). Previously, imatinib resistance in CML was treated with nilotinib as a second line. However, in Indonesia, where the options of TKIs are limited, no case has been reported. We describe TKI-resistance of a pediatric CML case in Dharmais Cancer Hospital, Jakarta. A 17-year-old boy presented with loss of complete hematologic response after 4 years of imatinib treatment. Diagnosis of relapsed CML with blast crisis was confirmed, and nilotinib was given accordingly. He achieved hematological and optimal response after 2 weeks and 3 months of treatment, respectively. However, in the 12-month evaluation, he failed to achieve major molecular response and acquired the second resistance to TKI. Since matinib
resistance marks the poor prognosis, initial optimal response of nilotinib treatment remains inconclusive to predict the final outcome.
resistance marks the poor prognosis, initial optimal response of nilotinib treatment remains inconclusive to predict the final outcome.
Creator
Mururul Aisyi, Ayu Hutami Syarif, Nur Asih, Agus Kosasih
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
2021-01-01
Contributor
Sri Wahyuni
Rights
ISSN : 0853-1773
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Files
Citation
Mururul Aisyi, Ayu Hutami Syarif, Nur Asih, Agus Kosasih, “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Tyrosine Kinase Inhibitor Resistance in Pediatric Chronic Myeloid Leukemia: A Case Report,” Repository Horizon University Indonesia, accessed October 31, 2025, https://repository.horizon.ac.id/items/show/904.
Tyrosine Kinase Inhibitor Resistance in Pediatric Chronic Myeloid Leukemia: A Case Report,” Repository Horizon University Indonesia, accessed October 31, 2025, https://repository.horizon.ac.id/items/show/904.