Unexpected carboxyhemoglobin half‐life during cardiopulmonary resuscitation: a case report
Dublin Core
Title
Unexpected carboxyhemoglobin half‐life during cardiopulmonary resuscitation: a case report
Subject
Carbon monoxide poisoning, Cardiac arrest, Cardiopulmonary resuscitation, Carboxyhemoglobin half-life, Case report
Description
Background Cardiac arrest (CA) following CO poisoning (CO-induced CA) exposes patients to an extremely high risk
of mortality and remains challenging to treat effectively. Terminal carboxyhemoglobin elimination half-life (COHbt1/2)
is critically affected by ventilation, oxygen therapy, and cardiac output, which are severely affected conditions in cases
of CA.
Case presentation Asystole occurred in an 18-year-old woman after unintentional exposure to CO in her bathroom.
Cardiopulmonary resuscitation (CPR) was started immediately, including mechanical ventilation with a fraction of
inspired oxygen (FiO2) of 1.0 and external chest compressions with a LUCAS® device. CPR was stopped after 101 min,
as it was unsuccessful. During this period, we calculated a COHbt1/2 of 40.3 min using a single compartmental model.
Conclusions This result suggests that prolongation of CPR time needed to back COHb at 10%, a level more compat‐
ible with successful return of spontaneous circulation (ROSC), could be compatible with a realistic CPR time. Calculat‐
ing COHbt1/2 during CPR may help with decision-making regarding the optimal duration of resuscitation efforts and
further with HBO2 or ECLS. Further evidence-based data are needed to confirm this result.
of mortality and remains challenging to treat effectively. Terminal carboxyhemoglobin elimination half-life (COHbt1/2)
is critically affected by ventilation, oxygen therapy, and cardiac output, which are severely affected conditions in cases
of CA.
Case presentation Asystole occurred in an 18-year-old woman after unintentional exposure to CO in her bathroom.
Cardiopulmonary resuscitation (CPR) was started immediately, including mechanical ventilation with a fraction of
inspired oxygen (FiO2) of 1.0 and external chest compressions with a LUCAS® device. CPR was stopped after 101 min,
as it was unsuccessful. During this period, we calculated a COHbt1/2 of 40.3 min using a single compartmental model.
Conclusions This result suggests that prolongation of CPR time needed to back COHb at 10%, a level more compat‐
ible with successful return of spontaneous circulation (ROSC), could be compatible with a realistic CPR time. Calculat‐
ing COHbt1/2 during CPR may help with decision-making regarding the optimal duration of resuscitation efforts and
further with HBO2 or ECLS. Further evidence-based data are needed to confirm this result.
Creator
Nicolas Delvau1* , Andrea Penaloza1
, Véronique Franssen1
, Frédéric Thys2
, Pierre‐Marie Roy3 and
Philippe Hantson4
, Véronique Franssen1
, Frédéric Thys2
, Pierre‐Marie Roy3 and
Philippe Hantson4
Source
https://doi.org/10.1186/s12245-023-00492-2
Date
2023
Contributor
peri irawan
Format
pdf
Language
english
Type
text
Files
Collection
Citation
Nicolas Delvau1* , Andrea Penaloza1
, Véronique Franssen1
, Frédéric Thys2
, Pierre‐Marie Roy3 and
Philippe Hantson4, “Unexpected carboxyhemoglobin half‐life during cardiopulmonary resuscitation: a case report,” Repository Horizon University Indonesia, accessed April 26, 2026, https://repository.horizon.ac.id/items/show/12121.