Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Association between SOX2 and OCT4 Expression and The Chemoradiation Therapeutic Response in Undifferentiated Non-Keratinizing Nasopharyngeal Carcinoma
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Title
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Association between SOX2 and OCT4 Expression and The Chemoradiation Therapeutic Response in Undifferentiated Non-Keratinizing Nasopharyngeal Carcinoma
Association between SOX2 and OCT4 Expression and The Chemoradiation Therapeutic Response in Undifferentiated Non-Keratinizing Nasopharyngeal Carcinoma
Subject
nasopharyngeal carcinoma, OCT4, SOX2
Description
BACKGROUND Self-renewal ability of cancer stem cells (CSS) is one of the possible causes for nasopharyngeal carcinoma (NPC) to relapse and metastasize. SOX2 and OCT4 are markers for expression of the embryonic stem cells and crucial for the progression of various malignancies. This study was aimed to analyze the association between SOX2 and OCT4 expression and chemoradiation therapeutic response in undifferentiated non-keratinizing NPC.
METHODS This cross-sectional study used archival data from Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto
Mangunkusumo Hospital from January 2014 to December 2016. The outcomes were classified into good-response (complete and partial response) and poor-response groups (progressive and stable disease) based on response evaluation criteria in solid tumors (RECIST). SOX2 and OCT4 immunohistochemistry staining was performed
using the initial specimen (before chemoradiation therapy) and positively expressing tumor cells were counted. Staining intensity was graded as: strong, moderate, weak, and negative. Strong and moderate staining was considered positive expression.
RESULTS 33 males and 8 females were included; 48% were ≥50 years old. Most of the patients had stage IV (n = 35) and several patients had stage II (n = 3) and III (n = 3). More cells expressed OCT4 in the good-response group than the poor-response group
(61.3% versus 37.0%, p = 0.009). Meanwhile, there were less cells expressing SOX2 in the good-response group than the poor-response group (36.3% versus 61.1%, p = 0.097).
CONCLUSIONS This study suggests that OCT4 is a potential predictive marker for therapeutic response in patients with NPC.
METHODS This cross-sectional study used archival data from Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto
Mangunkusumo Hospital from January 2014 to December 2016. The outcomes were classified into good-response (complete and partial response) and poor-response groups (progressive and stable disease) based on response evaluation criteria in solid tumors (RECIST). SOX2 and OCT4 immunohistochemistry staining was performed
using the initial specimen (before chemoradiation therapy) and positively expressing tumor cells were counted. Staining intensity was graded as: strong, moderate, weak, and negative. Strong and moderate staining was considered positive expression.
RESULTS 33 males and 8 females were included; 48% were ≥50 years old. Most of the patients had stage IV (n = 35) and several patients had stage II (n = 3) and III (n = 3). More cells expressed OCT4 in the good-response group than the poor-response group
(61.3% versus 37.0%, p = 0.009). Meanwhile, there were less cells expressing SOX2 in the good-response group than the poor-response group (36.3% versus 61.1%, p = 0.097).
CONCLUSIONS This study suggests that OCT4 is a potential predictive marker for therapeutic response in patients with NPC.
Creator
Lisnawati Rachmadi, Kusmardi, Monik Ediana Miranda, Maria Mayella Vianney
Publisher
Fakultas Kedokteran Universitas Indonesia
Date
2021-01-01
Contributor
Sri Wahyuni
Rights
ISSN : 0853-1773
Format
PDF
Language
English
Type
Text
Coverage
Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Files
Citation
Lisnawati Rachmadi, Kusmardi, Monik Ediana Miranda, Maria Mayella Vianney, “Jurnal Internasional Medical Journal of Indonesia FKUI Vol. 29 No. 4 2020
Association between SOX2 and OCT4 Expression and The Chemoradiation Therapeutic Response in Undifferentiated Non-Keratinizing Nasopharyngeal Carcinoma,” Repository Horizon University Indonesia, accessed October 13, 2024, https://repository.horizon.ac.id/items/show/902.
Association between SOX2 and OCT4 Expression and The Chemoradiation Therapeutic Response in Undifferentiated Non-Keratinizing Nasopharyngeal Carcinoma,” Repository Horizon University Indonesia, accessed October 13, 2024, https://repository.horizon.ac.id/items/show/902.